摘要
目的探讨女性支原体属、衣原体属感染与不孕的关系,指导临床治疗,提高不孕患者的治愈率。方法选择医院2009年1月-2010年4月就诊不孕患者356例,其中原发不孕136例,继发不孕220例,选正常生育妇女300例做对照组,取宫颈分泌物解脲脲支原体(Uu)、人支原体(Mh)、沙眼衣原体(Ct)培养,并对Uu感染做药物敏感试验,据药敏结果治疗。结果不孕组Uu阳性率为55.06%、Ct阳性率为4.49%、Ct+Uu阳性率为2.25%,对照组Uu阳性率24.67%、Ct阳性率为1.00%、Ct+Uu阳性率为0.33%。不孕组Uu、Ct、Ct+Uu阳性率明显高于对照组,经统计学处理,两者差异有统计学意义(P<0.05);继发不孕组Uu阳性率59.09%、Ct阳性率为5.00%,原发不孕组Uu阳性率为48.53%、Ct阳性率为3.68%,继发不孕组Uu、Ct阳性率明显高于原发不孕组,但经统计学处理,两者差异无统计学意义;Uu感染对普那霉素、交沙霉素、多西环素、四环素敏感。结论生育期女性生殖道感染Uu、Ct者是导致不孕的主要因素,对不孕妇女常规进行Uu、Ct检测,同时做药物敏感试验,有利于提高不孕患者的治愈率,控制耐药菌株的产生。
OBJECTIVE To explore the relationship between mycoplasma, chlamydia infection and Infertility for Women, guide the clinical treatment, and improre the cure rate of infertility patients. METHODS A total of 356 cases of infertility patients in our hospital were selected from Jan 2009 to Apr 2010, 136 cases of primary infertility,220 cases of secondary infertility. Totally 300 cases of normal fertile women were selected as control group. Mycoplasma （Ureaplasma urealyticum Uu, Mycoplasma hominis Mh） and Chlamydia trachomatis （Ct） culture with discharge of the cervix and drug sensitivity test for Uu infection, treat according to drug sensitivity. RESULTS In infertility group, the positive rate of Uu was 55.06~, that of Ct was 4.49~, that of Ct＋Uu was 2.25%, In control group, the positive rate of Uu was 24. 67%, that of Ct was 1. 00%, that of Ct-b Uu was 0.33%. The positive rate of UU, CT,CTA-UU in Infertility group was significantly different from control group according to the statistics （P〈0.05）, In secondary infertility group, the positive rate of Uu was 59.09% ,that of Ct was 5.00%, In primary infertility group, the positive rate of Uu was 48.53% ,that of Ct was 3.68%. Uu, Ct infection in secondary infertility was obviously higher than primary infertility group, But the difference was not significant according to the statistics （P〉0. 05）, Uu infection was sensitive to pristinamycin, josamycin, doxycyeline and tetracycline. CONCLUSION Infection Uu and Ct in reproductive tract is the main factor leading to infertility. Conventional Uu, Ct detection to sterile women, and drug sensitivity test at the same time can help to improve the cure rate of infertility, and control the occurrence of drug resistant strains.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第5期1050-1052,共3页
Chinese Journal of Nosocomiology
关键词
不孕
解脲脲支原体
人支原体
沙眼衣原体
药敏试验
Fertility
Ureaplasma urealyticum
Mycoplasma hominis
Chlamydia trachomatis
Drug sensitivitytest
