摘要
研究茶多酚对细胞膜脂质过氧化损伤的作用。方法采用３种自由基生成体系诱导红细胞膜脂质过氧化，脂质过氧化物用硫代巴比妥酸比色法测定。结果茶多酚对黄嘌呤－黄嘌呤氧化酶系统、Ｈ２Ｏ２及ＵＶ照射三种方法引起的细胞膜硫代巴比妥酸反应物（ＴＢＡＲＳ）生成增加均有抑制作用，其作用呈剂量依赖性，ＩＣ５０分别为２．２９、１．６５和２．７３ｍｍｏｌＬ－１。结论茶多酚对自由基引起的细胞膜脂质过氧化损伤有保护作用。
Objective: To investigate the effects of Tea Polyphenol on lipid peroxidation damage of erythrocyte membrane induced by radicals.METHODS: The lipid peroxidation of erythrocyte membrane induced by radicals derrived from threee radicals generation systems models was measured by thiobarbituric acid spectrophotmetry. RESULTS: Tea Polyphenol doesdependently inhibited the increases of thiobabituric acid reactve substance (TBARS) content in the membrane exposed to xanthinexanthine oxidase system,H2O2 or UV light.The IC50 were 229,165 and 2.73 mmolL-1,respectively.HZCONCLUSION: Tea Polyphenol may protect erythrocyte membrane from the lipid peroxidative damage induced by radicals.
出处
《中国中医基础医学杂志》
CAS
CSCD
1999年第8期28-31,共4页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
茶多酚
自由基
红细胞膜
脂质过氧化
Tea PolyphenolRadicalErythrocyte MembraneLipid peroxidation
