摘要
目的：探讨制备１∶１型及２∶１型的β环糊精双氯芬酸钠包合物可行性，了解对双氯芬酸钠溶解度的影响。方法：用液相法制备β环糊精双氯芬酸钠包合物，经过含量分析测定溶解度。结果：按不同反应物配比可以得到１∶１型和２∶１型包合物，其熔点分别为２９９－３００．５℃和３０２～３０３℃。结论：与单药相比，１∶１型和２∶１型包合物的溶解度分别增大０．
OBJECTIVE:Probe into the feasibility of preparation of diclofenac sodium with β cyclodextrins in 1∶1 and 2∶1 inclusion compounds ,and find out the affection in solubility of diclofenac sodium. METHODS:The 1∶1 and 2∶1 melusion compounds were prepared by liquid phase an alysis the content and determination them solubility.RESULT:The 1 ∶1 and 2∶1 inclusion compounds were prepared by different ratio of reactants and etermined them mp were 299～300.5℃ and 302～303℃ respectively. CONCLUSION:Of us is that solubilits of the 1∶1 and 2∶1 inclusion compounds increase 0.65 and 1 times respetively comparing with declofenac sodium.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
1999年第3期165-167,共3页
Chinese Pharmaceutical Journal
关键词
环糊精
包合比
溶解度
双氯芬酸钠
diclofenac sodium,cyclodextrins,inclusion ratio,solubility,ultraviolet speetra
