摘要
本文选用共沉淀法制备了吲哚美辛－β－环糊精包合物（简称包合物）。经Ｘ－射线衍射法、差热分析法以及ＮＭＲ法进行鉴定，证明吲哚美辛与β－环糊精（简称β－ＣＤ）确已形成包合物，吲哚美辛的苯环部分被个β－ＣＤ包合；含量测定证明主、客分子比为１∶１；经溶出度测定，包合物可明显提高吲哚美辛的溶解度及溶解速度。
The complex of indomethacin-β-CD was produced by co-precipitating method.Structure examination of X-ray diffraction,differential scanning calorimetric method and nuclearmagnetic resonance, proved that the benzyl moiety of indomythacin was enveloped by β-CD.Quantitative analysis demmonstrated that the molecular ratio of indomethacin to β-CD in thecomplex was 1∶1,and that the solubility and dissolution rate of indomethacin were promotedwhen the drug was wrapped by β-CD.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1994年第5期279-281,共3页
Chinese Pharmaceutical Journal
关键词
吲哚美辛
Β-环糊精
溶出度
indomethacin
β-cyclodextrian
complex
solubility
