摘要
目的:评价我院万古霉素血药浓度监测及其临床应用情况。方法:采用回顾性调查方法,对我院2005年11月～2008年12月应用万古霉素并监测血药浓度的41例住院患者的临床资料(基础疾病、细菌学培养结果、万古霉素血药浓度值、疗效、肾功能情况等)进行统计、分析。结果:我院住院患者应用万古霉素的总有效率为65.0%;万古霉素血药浓度所测得峰值<25mg.L-1者占62.7%,谷值<5mg.L-1者占55.2%;治疗后肾功能异常发生率为12.2%。结论:我院住院患者万古霉素应用量和血药浓度均偏低,需重视其血药浓度监测并结合临床实际,实现个体化给药。
OBJECTIVE：To evaluate clinical utilization and blood concentration monitoring of vancomycin in our hospital. METHODS： By retrospective survey method, the clinical information （primary diseases, bacteriological culture, blood concentration of vancomycin, clinical efficacy, renal function） of 41 inpatients who had been treated with vancomycin and their blood concentrations from Nov. 2005 to Dec. 2008 were analyzed statistically. RESULTS： The total response rate of vancomycin was 65.0%. The peak concentration of 62.7% cases were below 25 mg·L-1 while the valley value of 55.2% cases were below 5 mg·L-1. The incidence of renal dysfunction after treatment was 12.2%. CONCLUSION： The consumption and blood concentrations of vancomycin are close to low level in our hospital. It should be paid attention to the blood concentration monitoring of vancomycin to achieve an ideal individual administration according to clinical practice.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第26期2430-2432,共3页
China Pharmacy
关键词
万古霉素
血药浓度监测
临床用药
Vancomycin
Blood concentration monitoring
Clinical use of drugs
