摘要
目的通过分析123例患者万古霉素血药浓度的监测结果,为临床合理用药提供参考。方法采用回顾性调查方法,对本院2010年1月～2011年1月应用万古霉素并监测血药浓度的123例住院患者的临床资料(基础疾病、细菌学培养结果、万古霉素血药浓度值、疗效、肾功能情况等)进行统计、分析。结果本院住院患者应用万古霉素的总有效率为69.11%;万古霉素血药浓度所测得峰值<30μg/mL者占60.18%,<10μg/mL者占13.85%;治疗后肾功能异常发生率为12.20%。结论本院住院患者万古霉素应用量和血药浓度均偏低,需重视其血药浓度监测并结合临床实际,实现个体化给药。
Objective To provide reference for rational clinical drug use through analyzing the blood concentration monitoring results of 123 patients. Methods Clinical information （underlying diseases, bacteriology culture results, vancomycin blood concentration value, efficacy, conditions of renal function, etc.） of 123 hospitalized patients received vancomycin and blood concentration monitoring in our hospital from January 2010 to January 2011 was analyzed retrospectively. Results The total effective rate of vancomycin was 69.11% for the hospitalized patients in our hospital. The patients with a peak blood concentration 〈 30 μg/mL accounted for 60.18% and those 〈 10 μg/mL accounted for 13.85%. The abnormal renal function rate after treatment was 12.20 %. Conclusion The application dosage and blood concentration of vancomycin are low for the hospitalized patients in our hospital, thus it is important to pay attention to the blood drug concentration monitoring and combine clinical practice in order to achieve individual administration.
出处
《中国当代医药》
2013年第13期65-66,共2页
China Modern Medicine
关键词
万古霉素
血药浓度
临床用药
个体化
Vancomycin
Blood concentration
Clinical drug use
Individualization
