摘要
目的探讨血清胱抑素C、尿微量蛋白(β2-微球蛋白、α1-微球蛋白、转铁蛋白、微量白蛋白)联合检测在万古霉素致早期肾损害中的临床价值。方法 40例耐甲氧西林金黄色葡萄球菌(MRSA)肺部感染患者,应用万古霉素治疗前后联合检测血清胱抑素C、尿微量蛋白的变化。结果 40例MRSA肺部感染患者应用万古霉素治疗后,血清胱抑素C、尿微量蛋白阳性率明显高于血肌酐、尿素氮和尿常规阳性率(P均<0.05)。老年患者万古霉素治疗后血清胱抑素C、尿微量蛋白阳性率明显高于中青年患者(P均<0.05)。结论老年人应用万古霉素较为安全,血清胱抑素C、尿微量蛋白联合检测可早期发现万古霉素所致肾损害。
Objective To investigate the clinical value of combined measurement of serum levels of cystatin C and urinary microproteins（β2-MG,α1-MG,TRF and mAlb）in patients with early renal injury caused by vancomycin.Methods Changes of serum cystatin C and urinary microproteins were combined measured in 40 patients with pulmonary infection of methicillin resistant staphylococcus aureus（MRSA）before and after treatment.Results The positive rate of serum cystatin C and urinary microproteins were significantly higher than those of serum creatinine,blood urea nitrogen and routine urine test（P〈0.05）.The positive rates of serum cystatin C and urinary microproteins in elderly patients were significantly higher than those of the younger patients（P all0.05）.Conclusion Application of vancomycin in elderly patients with pulmonary infection by MRSA is safe.Combined measurement of the serum levels of cystatin C and urinary microproteins can early detect the renal injury by vancomycin.
出处
《实用药物与临床》
CAS
2012年第5期276-278,共3页
Practical Pharmacy and Clinical Remedies
基金
上海市干部保健局科研基金资助项目(2011GB24)
关键词
万古霉素
肾功能
胱抑素C
尿微量蛋白
Vancomycin
Renal functions
Cystatin C
Urinary microproteins
