摘要
目的探讨一氧化氮等自由基与脑出血的关系。方法检测１３３例脑出血患者和１００例健康对照者血浆一氧化氮（Ｐ－ＮＯ）、维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）和过氧化脂质（Ｐ－ＬＰＯ）含量及红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）、过氧化氢酶（Ｅ－ＣＡＴ）、谷胱甘肽过氧化物酶（Ｅ－ＧＳＨ－Ｐｘ）活性和过氧化脂质（Ｅ－ＬＰＯ）含量。结果与对照组比较，患者组Ｐ－ＮＯ、Ｐ－ＬＰＯ、Ｅ－ＬＰＯ均值显著升高（Ｐ＜０．００１），Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ、Ｅ－ＳＯＤ、Ｅ－ＣＡＴ、Ｅ－ＧＳＨ－Ｐｘ均值显著降低（Ｐ＜０．００１）；逐步回归发现，患者病情（ＮＤＳ）与Ｐ－ＮＯ、Ｐ－ＶＣ、Ｅ－ＬＰＯ值相关最为密切，颅内血肿量与Ｐ－ＮＯ、Ｐ－ＶＥ、Ｅ－ＬＰＯ值相关最为密切。结论脑出血患者体内自由基反应病理性加剧。
Objective\ To study the correlation among nitric oxide,other free
radicals and cerebral hemorrhage.Methods\ Nitric oxide(P NO),vitamin C(P VC),vitamin E(P
VE),β carotene (P β CAR),lipoperoxides (P LPO) in plasma,and superoxide dismutase (E
SOD),catalase(E CAT),glutathione peroxidease(E GSH PX) and lipoperoxides(E LPO) values in
erythrocyte were measured in 133 patients with cerebral hemorrhage and in 100 healthy control
persons.Results\ Compared with the control group,the average values of P NO,P LPO and E
LPO in the patient group were significantly increased,while the average values of P VC,P VE,P
β CAR,E SOD,E CAT and E GSH PX were markely decreased ( P <0.001).The stepwise
regression analysis showed that the NDS was closely related to the values of P NO.P VC,E
LOP,and that the intracranial hematoma size was closely related to the values of P NO,P VE,E
LPL.Conclusions\ The free radical reactions in the patients with cerebral hemorrhage were
pathologically exacerbated,and the balance between the oxidation and antioxidation was
markedly disturbed.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1999年第2期68-70,共3页
Chinese Journal of Gerontology
基金
浙江省医学科学科研基金
关键词
一氧化氮
自由基
脑出血
抗氧化剂
抗氧化酶
Nitric oxide\ Free radicals\ Cerebal hemorrhage\ Antioxidants\
Antioxidases\ Lipoperoxides
