摘要
目的探讨脑出血与一氧化氮、抗氧化剂的关系及其临床意义。方法检测９８例脑出血患者和１００例健康对照者的血浆一氧化氮（Ｐ－ＮＯ）、维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）含量，采用直线回归和相关、逐步回归等分析患者病情（临床神经功能缺损程度积分，ＮＤＳ）以及颅内血肿量与上述指标的关系。结果与对照组比较，观察组的Ｐ－ＮＯ平均值显著升高（Ｐ＜０．０１），Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ平均值均显著降低（Ｐ＜０．０１）；逐步回归分析发现，患者ＮＤＳ与Ｐ－ＮＯ、Ｐ－ＶＣ值相关最为密切，颅内血肿量与Ｐ－ＮＯ、Ｐ－ＶＥ值相关最为密切。结论脑出血患者体内ＮＯ代谢反应异常，氧化。
Objective To study the correlation between cerebral hemorrhage,nitric oxide and antioxidants and its clinical significance. Methods The plasma nitric oxide (PNO),plasma vitamin C(PVC),plasma vitamin E(PVE) and plasma βcarotene (PβCAR) contents were measured in 98 patients with cerebral hemorrhage and in 100 healthy control persons.Linear regression and correlation,and stepwise regression were used to analyze the correlation between the patient condition (NDS),intracranial hematoma size and the above indices. Results Compared with the controls,the average value of PNO in the patients was significantly higher,while the average values of PVC,PVE and PβCAR were markedly lower (P<0001).The stepwise regression analysis showed that the NDS was closely related to the values of PNO and PVC,and that the intracranial hematoma size was closely related to the values of PNO and PVE. Conclusions The metabolic reaction of nitric oxide in patients with cerebral hemorrhage was abnormal,and the balance between the oxidation and antioxidation was markedly disturbed.
出处
《实用老年医学》
CAS
1998年第4期158-160,共3页
Practical Geriatrics
基金
浙江省医学科学科研基金
关键词
脑出血
一氧化氮
维生素C
维生素E
Cerebral hemorrhage Nitric oxide Vitamin C Vitamin E Beta carotene
