摘要
目的：探讨脑出血与一氧化氮、氧化、脂质过氧化的关系及临床意义。方法：检测98例脑出血患者以及100例健康人血浆一氧化氮（P-NO）、维生素C（P-VC）、维生素E（P-VE）、过氧化脂质（P－LPO）含量、血浆和红细胞超氧化物歧化酶（P-SOD、E-SOD）活性及红细胞过氧化脂质（E－LPO）含量，采用直线回归和相关、逐步回归分析患者病情（临床神经功能缺损程度积分，NDS）和颅内血肿量与上述指标的关系。结果：与对照组比较，患者组的P-NO、P－LPO、E-LPO平均值均显著升高（P＜0．001），P-VC、P-VE、P-SOD、E-SOD平均值均显著降低（P＜0．001）；逐步回归分析发现患者NDS与P-NO、P-VC、E-LPO值相关最为密切，颅内血肿量与P-NO、P-VE、E-LPO值相关最为密切。结论：脑出血患者体内自由基反应病理性加剧，氧化抗氧化平衡严重失调。
Aim: To study the correlations between cerebral hemorrhage and nitric oxide, oxidation,lipoperoxidation, and their clinical sighficance. Methods: The plasma nitric oxide (P-No), plasma vitamin C (P-VC), plasma vitamin E (P-VE), plasma lipoperoxides (P-LPO), plasma superoxide dismutase (P-SOD), erythrocyte superoxide dismutase (E-SOD) and erythrocyte lipoperoxides (E-LPO) values were mea sured in 98 patients with cerebral hemorrhage and in 100 healthy control persons. Linear regression and correla tion, stepwise regression were used to analyse the correlations between patient's condition, intracranial hemato ma size and each value. Results: Compared with those in the control group, the average values of P-NO, P-LPO and E-LPO in the patient group were significantly increased, while the average values of P-VC, P-VE,P-SOD, E-SOD were markedly decreased (P < 0.001). The stepwise regression analysis showed that the NDS was closely related to the values of P-NO, P-VC, E-LPO, and that the intracranial hematoma size was closely related to the values of P-NO, P-VE, E-LPO. Conclusion: The free radical reactions in the patients with cerebral hemorrhage were pathologically exacerbated, and the balance between the oxidation and antioxidation was markedly disturbed.
出处
《急诊医学》
CSCD
1998年第6期387-389,共3页
关键词
脑出血
一氧化氮
氧化
脂质过氧化
Cerebral hemorrhage Nitric oxide Oxidation Lipoperoxidation
