摘要
为了探讨胰岛淀粉样多肽（ＩＡＰＰ）在人胎阑尾中的个体发生及其与其他生物活性物质的关系，用免疫组织化学ＰＡＰ法，对３６例１２～３８周人胎阑尾中ＩＡＰＰ免疫反应性（ＩＲ）细胞、生长抑素（ＳＳ）－ＩＲ细胞和５－羟色胺（５－ＨＴ）－ＩＲ细胞进行定位研究。结果表明，胎１２周，阑尾上皮中已可见到ＳＳ－ＩＲ细胞，而ＩＡＰＰ－及５－ＨＴ－ＩＲ细胞于１４周才见到。在整个胎期，阑尾中的ＩＡＰＰ－及ＳＳ－ＩＲ细胞始终分散存在，数量较少；而５－ＨＴ－ＩＲ细胞数量随胎龄增长而发生变化，胎１５～２１周为高峰期。经邻片比较观察，未见到ＩＡＰＰ与ＳＳ或５－ＨＴ在同一细胞有共存现象。本研究表明，胎期阑尾的内分泌细胞已可合成ＩＡＰＰ、ＳＳ及５－ＨＴ。
In order to investigate the ontogeny of the islet amyloid polypeptide (IAPP) and explore the relationship between IAPP and other classical hormones in human fetal appendix, the localization of IAPP immunoreactive (IR) cells, somatostatin (SS) IR cells and 5 hydroxytryptaming (5 HT) IR cells in 36 human fetal appendix from 12 to 38 weeks of gestation was investigated with immunohistochemical PAP method. The results showed that at 12 week of fetal age, the SS IR cells were found in the appendix epithelium, but IAPP and 5 HT IR cells appeared at 14 week. In the whole fetus period, IAPP and SS IR cells appeared fewer and scattered, while the number of 5 HT IR cells changed with the gestation age, showed a peak from 15 to 21 weeks of gestation. As compared with adjacent sections, the co localization of IAPP with SS or 5 HT in the same cell was not found. The results indicated that IAPP,SS and 5 HT had been synthesized in endocrine cells of human fetal appendix.
出处
《解剖学报》
CAS
CSCD
北大核心
1998年第4期438-440,I010,共4页
Acta Anatomica Sinica
关键词
胰岛淀粉样多肽
5-羟色胺
阑尾
胚胎
人体
Islet amyloid polypeptide
Somatostatin
5 Hydroxytryptamine
Appendix
Human fetus
