摘要
用免疫组化ＰＡＰ法，显示胰岛ＩＡＰ－和Ｉｎｓ－ＩＲ细胞，观察大鼠实验性胃溃疡自愈期间胰岛ＩＡＰＰ－和Ｉｎｓ－ＩＲ细胞的形态计量变化。溃疡第４～１４天，胰岛ＩＡＰＰ－ＩＲ细胞的面数密度明显升高，第２１和２８天基本恢复正常；而Ｉｎｓ－ＩＲ细胞的面数密度，在溃疡第６和１０天显著下降，第２８天基本恢复正常。提示胰岛Ｂ细胞内ＩＡＰＰ和Ｉｎｓ以不同的方式参与了溃疡自愈过程的调节。
he changes of islet IAPP-and Ins-IR cells during experimental gastric ulcer in rats were observed by imniuno-histocliemical PAP method, and analysed by morphornetry.It was shown that the numerical density on areas ofislet IAPP-IR cells increased significantly during 4-14 days after inducing ulcer; then returned gradurally to normallevel on the 21th and 28th day. However,the numerical density on areas of islet Ins-IR cells decreased obviouslyon the 6th and 10th day,and was back to normal level on the 28th day.These results indicated that IAPP and In-scoexisting in islet B-eells changed contrary each other during ulcer healing.The present work suggests that IAPP andIns may participate in the regulation of the healing process of gastric ulcer.
出处
《北京医科大学学报》
CSCD
1995年第5期333-335,346,I028,共4页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
大鼠
胃溃疡
自愈
胰岛
细胞学
Headings lslet amyloid polypeptide(IAPP)
Insulin (Ins)
Stomach ulcer
Islands of landerhans cytol
