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染料木黄酮对小鼠子宫内膜癌c-fos、cj-un mRNA表达的影响 被引量：1

Effects of Genistein on the expression of c-fos,c-jun mRNA in mice endometrial cancer
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摘要 目的探讨染料木黄酮对雌二醇-17β(E2)所诱发的小鼠子宫内膜癌c-fos、c-jun mRNA表达的影响。方法利用免疫组化方法和定量RT-PCR法检测小鼠子宫内膜癌细胞c-fos、c-jun mRNA的表达量。结果E2单独投与群c-fos、c-jun mR-NA表达增强,与E2单独投与群比较,E2和染料木黄酮联合投与群明显抑制E2刺激所诱发的c-jun表达增强。c-fos mRNA表达有减少趋势。结论E2皮下注射的雌性ICR小鼠给予染料木黄酮后c-fos、c-jun mRNA表达减少,对子宫内膜癌的预防有一定的意义。 Objective To study the effect of Genistein on the expression of c-fos,c-jun mRNA in Estrogin（E2）-induced endometrial cancer in ICR mice and study it′s preventive value for tumor.Mothods Immunohistochemical method and real time RT-PCR technique to detect the expression level of c-fos,c-jun mRNA in the endomtrial cancer cell in ICR mice.Results When Estrogin（E2） was given alone,the expression of c-fos,c-jun mRNA increased significantly.While Estrogin（E2） and Genistein were given together,Genistein significantly decreased the expression of c-fun which was induced by Estrogin（E2）.The expression of c-fos also had a decreasing dendency.Conclusion When female ICR mice with s.c injection of Estrogin（E2） were given Genistein,the expression of c-fos,c-jun mRNA decreased.It had certain significance for the prevention of endometrial cancer.
作者 尹香花 李虹娇 李俊霞
机构地区 扬州大学临床医学院妇产科 吉林延边大学附属医院妇产科
出处 《实用临床医药杂志》 CAS 2009年第12期22-25,共4页 Journal of Clinical Medicine in Practice
基金 国家自然科学基金资助项目(30460135)
关键词 染料木黄酮 c-fos、c-jun基因 小鼠子宫内膜癌 genistein c-fos 、c-jun gene endometrial cancer
分类号 R737.33 [医药卫生—肿瘤]
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  • 1[1]MacDonald IC,Groom AC,Chambers AF.Cancer spread and micrometastasis development:quantitative approaches for in vivo models.Bioessays 2002; 24:885-893
  • 2[2]Onishi A,Nakashiro K,Mihara M,Sumida T,Kawamata H,Shintani S,Aida T,Tachikawa T,Hamakawa H.Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer.Oncol Rep 2004; 11:33-39
  • 3[3]Shingu K,Helfritz A,Kuhlmann S,Zielinska-Skowronek M,Jacobs R,Schmidt RE,Pabst R,von Horsten S.Kinetics of the early recruitment of leukocyte subsets at the sites of tumor cells in the lungs:natural killer (NK) cells rapidly attract monocytes but not lymphocytes in the surveillance of rnicrometastasis.Int J Cancer 2002; 99:74-81
  • 4[4]Higashi N,Ishii H,Fujiwara T,Morimoto-Tomita M,Irimura T.Redistribution of fibroblasts and macrophages as micrometastases develop into established liver metastases.Clin Exp Metastasis 2002; 19:631-638
  • 5[5]Olaso E,Salado C,Egilegor E,Gutierrez V,Santisteban A,Sancho-Bru P,Friedman SL,Vidal-Vanaclocha F.Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis.Hepatology 2003; 37:674-685
  • 6[6]Ishikura H,Kondo K,Miyoshi T,Kinoshita H,Hirose T,Monden Y.Artificial lymphogenous metastatic model using orthotopic implantation of human lung cancer.Ann Thorac Surg 2000; 69:1691-1695
  • 7[7]Taback B,Hashimoto K,Kuo CT,Chan A,Giuliano AE,Hoon DS.Molecular lymphatic mapping of the sentinel lymph node.Am J Pathol 2002; 161:1153-1161
  • 8[8]Mochizuki Y,Nakanishi H,Kodera Y,Ito S,Yamamura Y,Kato T,Hibi K,Akiyama S,Nakao A,Tatematsu M.TNFalpha promotes progression of peritoneal metastasis as demonstrated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line.Clin Exp Metastasis 2004; 21:39-47
  • 9[9]Mori T,Fujiwara Y,Sugita Y,Azama T,Ishii T,Taniguchi K,Yamazaki K,Takiguchi S,Yasuda T,Yano M,Monden M.Application of molecular diagnosis for detection of peritoneal micrometastasis and evaluation of preoperative chemotherapy in advanced gastric carcinoma.Ann Surg Oncol 2004; 11:14-20
  • 10[10]Fujiwara Y,Ooka M,Sugita Y,Sakita I,Tamaki Y,Monden M.Prevention of cross-contamination during sampling procedure in molecular detection for cancer micrometastasis.Cancer Lett 2000; 153:109-111

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同被引文献14

  • 1王毅,林伟,施举红.野百合碱处理大鼠肺动脉高压模型的塑造[J].浙江临床医学,2007,9(6):749-750. 被引量：7
  • 2Sawamura F, Kato M, Fujita K, et al. Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotalineqnduced pulmonary artery hypertension in rats[J]. J Pharmacol Sci, 2009, 111(3): 235-43.
  • 3陈洪麓 段云友 周宁 等.实时超声监测兔慢幽市动脉高压模型的建立及其意义.中国超-医学杂忠,2008,24(8):864-864.
  • 4Ichinose F, Erana-garcia J, Hromi J, et al. Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension[J]. Crit Care Med, 2001, 29(5): 1000-5.
  • 5Schober KE, Baade H. Doppler echocardiographic prediction of pulmonary hypertension in West Highland white terriers with chronic pulmonary disease[J]. J Vet Intern Med, 2006, 20(4): 912-20.
  • 6Berg R, Pehlemann K. Anatomic studies of the pulmonary hypertension syndrome in the domestic pig [J]. Anat Histol Embryol, 1987, 16(3): 265-70.
  • 7Stenmark KR, Meyrick B, Galie N, et al. Animal models ofpulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure[J]. Am J Physiol Lung Cell Mol Physiol, 2009, 297(6): L1013-32.
  • 8Henriques CT, Brand'o NA, Moreira GD, et al. Effects of TNF2alpha blockade in monocrotaline2induced pulmonary hypertension [J]. Rev Port Cardiol, 2008, 27: 3412348.
  • 9Schermuly RT, Kreisselmeier KP, Ghofrani HA, et al. Chronic sildenafil treatment inhibits monocrotaline induced pulmonary hypertension in rats [J]. Am J Respir Crit Care Med, 2004, 169: 39-45.
  • 10Takahashi H, Goto N, Kojima bone morpbogentic protein hypertension [J]. Am J Physiol (3): L450-8. Y, et al. Downregulation of type 11 receport in hypoxic pulmonary Lung Cell Mol Physiol, 2006, 290(3): L450-8.

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实用临床医药杂志
2009年 第12期

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