摘要
目的探讨磁共振1.5T单体素1H-MRS技术在肝硬化中的应用价值,对所得的波谱进行初步分析。方法对20名健康志愿者和20例肝硬化患者行常规MRI和MRS检查,利用Philip公司波谱软件包得出各波峰下面积进行比较。结果所有接受检查者均获得MRS结果。正常组Lip出现率100%,Cho出现率为95.00%,Cr出现率为85.00%,Glx出现率为80.00%,肝硬化组Lip出现率100%,Cho出现率为100%,Cr出现率为70.00%,Lac出现率为75.00%。Glx峰在肝硬化组病例中出现率仅为为20.00%,正常组中无乳酸峰。两组中Lip峰下面积比较差异有统计学意义(P<0.01),而Cho和Cr峰下面积比较差异无统计学意义。结论单体素1H-MRS技术能够分析肝硬化病理改变后的各代谢物质的变化,是无创性检查和评估肝硬化的一种可行方法。
Objective To approach the value of a H-MRS in the diagnosis of the hepatic cirrhosis and to study the changes of the spectrum obtained. Methods Twenty healthy subjects and 20 hepatic cirrhosis subjects underwent conventional MRI and 1^H-MRS of liver. The areas within the spectras were obtained and compared. Results The frequency of Lip, Cho, Cr, and Glx was 100%, 95.00%, 85.00% and 80.00% in healthy subjects, respectively, and the frequency of Lip, Cho, Cr, Lac, and Glx was 100%, 100%, 70. 00%, 75.00% and 20. 00% in hepatic cirrhosis patients, respectively. Lac was absent in healthy subjects. The frequency of Glx in hepatic cirrhosis was much lower than that in healthy subjects. The frequency of Lip between the two groups had significant difference （P〈0. 01）, although the frequency of Cho and Cr between the two groups had no significant difference. Conclusion The changes of metabolite in hepatic cirrhosis can be detected and analyzed with 1^H-MRS, which is a feasible, non-invasive technique in the diagnosis of hepatic cirrhosis.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第8期1433-1436,共4页
Chinese Journal of Medical Imaging Technology
基金
陕西省科技攻关项目(2004K12-G10)
关键词
磁共振成像
磁共振波谱
肝硬化
Magnetic resonance imaging
Magnetic resonance spectroscopy
Hepatic cirrhosis
