摘要
目的使用实验性兔肝纤维化模型探讨MR弥散加权成像(DWI)评价肝纤维化的能力。方法5只对照组兔和22只实验组兔进行DWI检查。兔肝纤维化模型使用腹腔注射CCl4诱导建立。根据病理组织学检查结果,所有动物肝脏纤维化分期为S0～S4,肝脏炎症活动度分级为G0～G4。DWI使用b值为600s/mm2,测量DWI图像信号强度值(SI)、表观弥散系数(ADC)和指数表观弥散系数(EADC),比较不同肝纤维化分期和不同肝炎症活动度分级时平均SI、ADC和EADC值变化。结果随肝纤维化分期进展,SI和EADC值逐渐升高、ADC值逐渐下降(P<0.05);随炎症活动度分级增加,SI值逐渐升高,ADC值和EADC值波动式下降和升高(P<0.05)。结论随肝纤维化分期和炎症活动度分级进展,SI和EADC上升,ADC下降。初步研究结果显示,DWI对于全面评价肝纤维化时肝纤维化分期和炎症活动度分级有重要价值。
Objective To investigate the ability of diffusion-weighted MRI （DWI） for evaluating hepatic fibrosis using an experimental rabbit hepatic fibrosis model. Methods Five rabbits of control group and 22 rabbits of experimental group were examined with DWI. Rabbit hepatic fibrosis models were induced by transperitoneal injection of CC14. All animals were graded by degree of fibrosis as S0-S4, and graded by inflammation activity as GO-G4 separately, based on histological examinations from excisional liver. Diffusion-weighted SE EPI sequence with a relatively high b factor （bl=0 s/mm^2, b2--600 s/mm^2） was used to measure DWI signal intensity （SI）, apparent diffusion coefficient （ADC） and exponential apparent diffusion coefficient （EADC） values. The mean value of SI, ADC and EADC was compared among different stage of hepatic fibrosis and among different grade of inflammation activity. Results The mean SI and EADC value increased, while ADC value decreased, as the severity of hepatic fibrosis increased （P〈0.05）. The mean SI value increased as the grade of inflammation activity increased, while ADC value decreased and EADC value increased fluctuately as the severity of inflammation progressed （P〈0.05）. Conclusion There is an increase of SI, EADC value and decrease of ADC value with increasing degrees of hepatic fibrosis as well as inflammation activity. The preliminary results demonstrate the potential usefulness of DWI for evaluation of fibrosis inflammation in the liver.
出处
《解剖学研究》
CAS
2007年第3期212-216,共5页
Anatomy Research
基金
国家自然科学基金(30670593)
关键词
肝纤维化
磁共振成像
弥散加权成像
兔
Hepatic fibrosis
Magnetic resonance imaging
Diffusion weighted imaging
Rabbit
