摘要
目的:探讨慢性乙型肝炎肝组织病变严重程度与血清脂质水平的关系．方法:采用全自动生化分析仪测定130例慢性乙型肝炎患者和30例正常人血清总胆固醇 (TC)、甘油三酯(TG)、高密度脂蛋白胆固醇 (HDL-C)、低密度脂蛋白胆固醇(LDI-C)、极低密度脂蛋白胆固醇(VLDL-C),并与慢性乙型肝炎患者肝组织病理分级分期进行对比分析．结果:慢性乙型肝炎患者血清的脂质水平随着肝组织炎症程度加重、肝组织纤维分期升高而逐渐降低,较重的肝组织炎症活动程度 (G3、G4)、较重的肝组织纤维分期(S4)与对照组比较,有显著差异(P<0．05或<0．01),较轻的肝组织炎症活动程度(G1、G2)、较轻的肝组织纤维分期(S0、S1、S2、S3)与对照组比较,差异不显著(P>0．05)．结论:测定血清脂质水平对判断较重的慢性肝炎肝组织实质细胞的损害和预后估计有一定的价值．
AIM： To investigate the relationship between the severity of liver histology and serum lipid level in patients with chronic hepatitis B. METHODS： The serum levels of total cholesterol （TC）, triglycerides （TG）, high density lipoprotein-cholesterol （HDL-C）, low density lipoprotein-cholesterol （LDL-C）, and very low density lipoprotein-cholesterol （VLDL-C） was measured and compared in 130 chronic hepatitis B patients and 30 healthy controls with automatic biomedical analyzer. RESULTS： The levels of serum lipid were decreased with the enhancement of histological inflammation grading and fibrosis staging, and they were significant ly different in patients with G3, G4 grades （for inflammation degree） and S4 stage （for fibrosis degree） than those in the controls （P 〈 0.05 or P 〈 0.01）. The levels of serum lipid in patients with G1, G2 grades and S0,S1, S2, S3 stages had no marked difference with those in the controls. CONCLUSION： The levels of serum lipid are useful for the judgment of the severe hepatic inflammation and prognosis.
出处
《世界华人消化杂志》
CAS
北大核心
2006年第4期453-456,共4页
World Chinese Journal of Digestology
关键词
慢性肝炎
血脂
病理分级分期
Chronic hepatitis
Serum lipid
Pathological grading and staging
