摘要
为探讨肺癌患者细胞免疫功能状态,测定31例肺癌患者外周血T细胞亚群(APAP法)、NK活性(LDH释放法)、SIL-2R水平(双抗体夹心法)。结果:患者CD_4^+细胞降低,CD_8^+细胞升高,CD_4^+/CD_8^+比值降低,血清SIL-2R水平升高,而NK活性较正常对照组无显著性差异。结论:肺癌患者细胞免疫功能明显下降,提高患者免疫功能将成为肺癌治疗的重要组成部分。
Objective: Investigate the status of the cellular immunity in primary lung cancer's patients. Method: We have mesured T-lymphocyte subsets, soluble interlcukin-2 recetor (SIL-2R) levels and activities of natural-kill cells in the peripheral blood of 31 patients with paimary lung cancer and 11 health subjects. Result: CD_(4)^+ subsets and ratioes of CD_(4)^+ /CD_(8)^+ in these patients were lower than those in health subjects, CD_(8)^+ subsets and the levels of SIL-2R in these patients were higher than those in health subjects, there was on significant differ in activities of NK cells be-tween these two groups. Conclusion: there be cellular-immunity disorder in primary lung cancer patients, increased the cellular-immunity functions will be the important component in the primary lung cancer's treatment.
出处
《河北医药》
CAS
1998年第4期195-196,共2页
Hebei Medical Journal
关键词
肺癌
T细胞亚群
SIL-2R
NK活性
双抗体夹心法
Lung cancer T-lymphocyte subsets Soluble interleukin 2 receptor Activities of natural-kill cells
