摘要
目的 为了观察肺癌患者红细胞免疫功能及T淋巴细胞亚群的变化。方法 采用检测 5 5例肺癌患者红细胞免疫功能及T淋巴细胞亚群 ,并与 1 5例肺良性肿瘤患者和 2 0例正常人对照。结果 (1 )肺癌组红细胞C 3b受体花环率 (RBC -C 3bRR)、CD 3+ 、CD 4+ 、CD 8+ 、CD 4+ /CD 8+ 比值低于正常人 (P <0 0 5～ 0 0 1 ) ,红细胞免疫复合物花环率(RBC -ICR)依次高于肺良性肿瘤组、正常人 (P <0 0 5～ 0 0 1 )。 (2 )肺癌RBC -C 3bRR与CD 4+ /CD 8+ 成直线正相关 (P <0 0 1 ,r =0 91 31 )。 (3)Ⅲa、Ⅲb期肺癌 ,RBC -C 3bRR、CD 3+ 、CD 4+ 、CD 4+ /CD 8+ 比值低于Ⅰ、Ⅱ期肺癌患者、正常人 (P <0 0 5～ 0 0 1 ) ,而RBC -ICR高于正常人 (P <0 0 1 )。Ⅰ、Ⅱ期病人CD 3+ 、CD 4+ 、CD 8+ 低于正常人 (P <0 0 1 ) ,RBC—ICR高于正常人 (P <0 0 1 )。 (4)术后 1 0～ 1 4d ,根治组与术前比较 :RBC -C 3bRR、CD 3+ 、CD 4+ /CD 8+ 比值显著升高 (P <0 0 1 ) ,而RBC -ICR、CD 8+ 显著降低 (P <0 0 1 ) ;术后与正常人比较 :RBC -C 3bRR、CD 4+ /CD 8+ 比值无显著差异 (P >0 0 5 )。姑息组与术前比较 :RBC -C 3bRR、CD 4+ 、CD 4+ /CD 8+ 比值显著升高 (P <0 0 5～ 0 0 1 ) ,而RBC -ICR?
Objective To study changes of erythrocyte immune function and T lymphocyte subsets in lung cancer patients. Methods Erythrocyte immune function and T lymphocyte subsets were detected in 55 lung cancer patients,compared with 15 patients with benign lung neoplasm and 20 healthy subjects as controls.Results (1)RRC-C 3 bRR,CD 3 +,CD 4 +,CD 8 + and CD 4 +/CD 8 + ratio in lung cancer patients were significantly lower than those in healthy subjects (P<0 05～0 01);however,RBC-ICR in lung cancer patients were significantly higher than those in patients with benign lung neoplasm and healthy subjects (P<0 05～0 01).(2)RBC-C 3 bRR and CD 4 +/CD 8 + ratio presented a linear positive correlation (r=0 9131,P<0 01).(3)RBC-C 3 bRR,CD 3 +,CD 4 +,and CD 4 +/CD 8 + ratio in patients with lung cancer stages Ⅲa and Ⅲb were significantly lower than those in stages Ⅰ and Ⅱ and healthy subjects (P<0 01),CD 3 +,CD 4 + ,and CD 8 +in stageⅠ,Ⅱ cancer patients were significantly lower than those in healthy subjects (P<0 01),and RBC-ICR in stage Ⅰ,Ⅱ cancer patets was significantly higher(P<0 01).(4)RBC-C 3 bRR,CD 3 + and CD 4 +/CD 8 + ratio in patients after radical resection cancer were significantly higher than those before operation (P<0 01) while RBC-ICR and CDB + were lower;there was no significant difference in RBC-C 3 bRR and CD 4 +/CD 8 + ratio between patients after operation and healthy subjects (P>0 05).RBC-C 3 bRR,CD 4 + and CD 4 +/CD 8 + ratio in patients after palliative resection were significantly higher than those before operation (P<0 05～0 01),RBC-ICR was lower (P<0 01) while CD 3 + and CD 8 + did not change,there was no significant difference in RBC-C 3 bRR and CD 4 +/CD 8 + ratio between patients after operation and healthy subjects (P>0 05).There was no significant difference in RBC immune function and T lymphocyte subsets between patients before and after exploratory operation.Conclusions Detection and correlation analysis of erythrocyte immune function and T lymphocyte subsets might be useful in diagnosis,treatment and prognostic assessment of lung cancer.
出处
《武警医学》
CAS
2000年第9期518-523,共6页
Medical Journal of the Chinese People's Armed Police Force
关键词
肺肿瘤
红细胞免疫功能
T淋巴细胞亚群
Lung neoplasm Erythrocyte immune function T lymphocyte subsets
