摘要
目的 观察肺癌患者不同组织学分型及不同TNM分期细胞免疫功能的变化。方法 采用SP及SAP法检测 10 6例肺癌患者Ｔ细胞亚群和ＮＫ细胞活性 ,与 46例正常人对照。结果 肺癌病人细胞免疫功能明显障碍 ,其ＮＫ细胞活性、ＣＤ3+ ,ＣＤ4 + 均显著降低 ,ＣＤ8+ 增加 ,致使ＣＤ4 + /ＣＤ8+ 比值下降 ;不同组织学分型的肺癌患者 ,未分化癌ＮＫ细胞活性比鳞癌低 (Ｐ <0 0 5 ) ,而ＣＤ8+ 则高于鳞癌 (Ｐ <0 0 5 ) ,其余无差异 :Ⅲ ,Ⅳ期ＮＫ细胞活性、ＣＤ3+ ,ＣＤ4 + ,ＣＤ8+ ,ＣＤ4 + /ＣＤ8+ 均低于Ｉ,Ⅱ期。结论 肺癌患者细胞免疫功能紊乱 ,Ｔ细胞亚群和ＮＫ细胞活性的检测对肺癌的诊断、疗效及预后具有一定的价值。
To study the change of cellular immune function in pathological classification and different TNM in patients with lung cancer.Methods T lymphocyte subsets were detected by Biotin-Streptavidin-Peroxidase,and NK activity was detected by Streptavidin-HRP/AP in serum in 106 patients with lung cancer.46 healthy persons were chosen as control.Results The cellular immune function of lung cancer patients was markedly impaired and NK activity,CD 3+,and CD 4+ were all remarkably decreased,while CD 8+ increased,thus ratio of CD 4+/CD 8+ decreased accordingly (P<0.01).NK activity in undifferent carcinoma was lower than in squamous cell carcinoma,but CD 8+was higher than in squamous cell carcinoma (P<0.05).CD 3+,CD 4+,CD 8+,and CD 4+/CD 8+ ratio of III?IV staged lung cancer patients were significantly lower than those of I?II staged.Conclusion The results reveal that the cellular immune function in patients with lung cancer was disorder remarkably.Detection of T lymphocyte subsets and NK activity may be useful in the diagnosis,treatment,and prognosis of lung camcer
出处
《云南医药》
CAS
2002年第6期437-439,共3页
Medicine and Pharmacy of Yunnan
