摘要
ｆｅｃｔｓｏｆｎｉｔｒｏｑｕｉｎｅｏｎｕｌｔｒａｓｔｒｕｃｔｕｒｅｓａｎｄｃｙｔｏｃｈｒｏｍｅｏｘｉｄａｓｅｏｆｅｘｏｅｒｙｔｈｒｏｃｙｔｉｃＰｌａｓｍｏｄｉｕｍｙｏｅｌｉｉｎｒａｔｌｉｖｅｒ１ＣＨＥＮＸｉａｏＨｏｎｇ２，ＨＵＹｏｕＭｅｉ，ＬＩＡ...
AIM: To study the effects of nitroquine acetate (NA) on the ultrastructures and cytochrome c oxidase(CCO) of exoerythrocytic forms (EEF) of Plasmodium yoelii . METHODS: Rats were inoculated with sporozoites directly into the liver. After 48 h rats were killed. Rat liver thin sections were incubated in histochemical reaction medium, then examined by transmission electron microscopy. NA (2 mg·kg -1 ) was fed to rats 3 5 h and 14 h before killing the rats. RESULTS: At 3 5 h, in the parasites there appeared swelling and proliferation of mitochondria, dilation of endoplasmic reticulum, and reduction of the electron density of parasites nuclei. The structures of the parasites disintegrated to form many autophagocytes 14 h after exposure to NA. The reaction products of CCO still existed until 14 h after using NA. CONCLUSION: CCO was not the starting point of NA action. NA interferes with the structure and function of the cytoplasm and nucleus of malaria parasites and exerts its antimalarial effects in many aspects.
出处
《中国药理学报》
CSCD
1998年第4期390-393,共4页
Acta Pharmacologica Sinica
关键词
硝基喹啉类
约氏疟原虫
细胞色素C
氧化酶类
肝
antimalarials
nitroquinolines
Plasmodium yoelii
electron microscopy
cytochrome c oxidase
liver
