摘要
本文综合报道了我们十几年来在硝喹与复方哨喹临床及现场与扩大使用方面的结果。治疗恶性疟198例,用50～75mg×3天(复方硝喹,下同),对恶性疟或抗氯喹恶性疟患者有良好的效果。治疗间日疟510例,当剂量为50mg×3天时,效果略逊于氯喹。在抗氯喹恶性疟地区的4540人群中进行防治验证,通过重点村寨详细观察认为:用50mg/天/半月或75mg×2天/月,均可达到防治效果。实验室研究表明本药对疟原虫的组织期、红内期、孢子增殖期均有作用,据此提出了复方硝喹的合理使用建议。
This is a comprehensive review of the work done on the clinical and field application by a team of a new antimalarial nitroquine.A total of 198 acute cases of plasmodium falciparum infection (both chloroquine sensitive and chloroquine-resistant) were treated with nirtoquine-composite 50-70 mg×3d with satisfactory results.The effect of treating 510 acute cases of P.vivax with nitroquine-composite 50 mg×3d was slightly less as compared with routine chloroquine treatment.The prophylactic trials made in 2 chloroquine resistant p.falciparum endemic areas among a total population of 4540 showed that when uitroquine-composite was given in dose of 50 mg/d/15d or 75mg/2d/m gives satisfactory prophylactic effects.Ladoratoty experiments show that nitroquine is effective to the tissue,erythrocytic and sporogonic stages of malaria parasites.A resouable scheme of medicating nitroquine is proposed.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1989年第4期281-284,共4页
Journal of Third Military Medical University
关键词
硝喹
抗疟药
疟疾
药物
autimalarials/PD
chloroquine/TU
nitroquine
nitroquine-composite
malaria/PC
sporogonic stage
