摘要
用干扰素诱导剂聚肌胞(Poly I:C)静脉注射(iv)Wistar大鼠体内,18h后,iv约氏疟原虫子孢子,42h时,肝内红外期(EEF)数量显著减少。其子孢子发育率仅为对照组的5—12％,但大小及成熟程度均未受到影响。接种子孢子后2h,使用Poly I:C,则子孢子发育率、EEF大小及成熟程度均与对照组无异。含干扰素血清与子孢子共孵40min,不影响子孢子的入侵及随后的发育。结果提示干扰素的抗疟作用并非针对EEF本身。
When Wistar rats were given intravenously with Poly I:C 5mg/kg 18h before sporo-zoite inoculation, the density of exoerythrocytic forms (EEF) in the rat liver 42h after inoculation was markedly decreased, the sporozoite viability being only 5-12% of that of the controls. However, the size and maturation rate of EEF were all normal. When Poly I:C was given 2h after sporozoite inoculation, the sporozoite viability and the size and the maturation rate of EEF were similar to those of the controls. When the sporozoites were inocubated with rat serum containing interferon for 40 min before inoculation, no detrimental effect on the sporozoite invasion and the development of EEF could be found. These findings suggested that the target of antimalarial action of interferon might not be the EEF itself. It is possible that interferon could minimize the sporozoite number by enhancing the phagocytosis and the biocidal activity of macrophages, especially the Kupffer cells.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1991年第3期186-189,共4页
Chinese Journal of Parasitology and Parasitic Diseases
基金
中国国家自然科学基金
关键词
约氏疟原虫
子孢子
红外期
聚肌胞
Plasmodium yoelii, sporozoite, exoerythrocytic forms, Poly I:C, rat.
