摘要
目的观测3种抗疟药对疟原虫诱导的大鼠腹腔巨噬细胞释放肿瘤坏死因子（TNF）的影响。方法：以酶联免疫法检测细胞培养液中TNF的含量。结果：感染约氏疟原虫的红细胞可诱导大鼠腹腔巨噬细胞释放TNF，12h时释出量达高锋。氯喹、硝喹明显抑制TNF的释放，乙胺嘧啶作用不明显。结论：氯喹、硝喹抑制TNF释放可能是其抗疟作用机制之一。
To examine the effect ofthree anti-malaria drugs on the release of tumornecrosis factor (TNF ) from rats peritonealmacrophages. METHOD Enzyme-linked mmunosorbant assay. RESULTS Erythrocyte in-fected by Plasmodium yoelii can induce TNF releasefrom macrophages;At 12th hour,the levelof TNF reaches its peak.Chloroqune and nitroquine have obious inhibitive effect on the releasing of TNF,but pyrimethamine shows no effect.CONCLUSIONS:The results suggest tha the inhibition of TNF may be a part of antimalaria effectof chloroquine and nitroquine.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第5期458-460,共3页
Chinese Pharmacological Bulletin
