摘要
目的:探讨枸杞叶茶水煎剂有无降血糖作用。方法:制备四氧嘧啶糖尿病小鼠模型后,将其分为模型对照组、降糖灵治疗组、低剂量枸杞叶茶治疗组、高剂量枸杞叶茶治疗组分别以灌服生理盐水、25mg/kg.d-1降糖灵水溶液、5.0g/kg.d-1枸杞叶茶水煎剂、7.5g/kg.d-1枸杞叶茶水煎剂处理14d后,测定小鼠空腹血糖。结果:给药后降糖灵治疗组、高剂量和低剂量枸杞叶茶治疗组血糖较给药前均有极显著降低(P<0.01)。给药前后降糖灵治疗组、两剂量枸杞叶茶治疗组小鼠血糖与模型对照组小鼠血糖变化值存在显著差异,而给药后降糖灵、高剂量和低剂量枸杞叶茶三个治疗组的差异不显著,说明枸杞叶茶的降血糖作用与降糖灵有同样的效果。高剂量枸杞叶茶治疗组的降糖率高于低剂量枸杞叶茶治疗组,说明枸杞叶茶水煎剂的降血糖作用与剂量有关。结论:一定剂量的枸杞叶茶水煎剂对四氧嘧啶糖尿病小鼠有明显的降血糖作用。
Objective： This article is designed to investigate weather Lycium harbarum L. leaf tea has certain functions of reducing blood glucose or not. Methods： Model of diabetes mellitus were induced by alloxan, then model rats were divided into four groups ： blank control group, positive control group, and experimental groups （low dose Lycium barbarum L. leaf tea group and high dose Lycium bar-barum L. leaf tea group） . In experimental groups, mice were fed with 5.0g/kg·d^-1 （low dose） or 7.5g/kg·d^-1 （ high dose） Lycium barbarum L. leaf tea respectively; in positive control group, mice were fed with phenformin; and in blank control, mice were fed with normal saline water. After 14 days＇ treatment, fasting blood glucose was measured. Results： Blood glucose of mice in positive control group and experimental groups after treatment were reduced most significantly compared to pretreatments （P〈0.01 ）, which was significantly different from blank control group. There was no difference among experimental groups and positive control group. The results indicated that both phenformin and Lycium harbarum L. leaf tea had significant function of reducing blood glucose. Furthermore, Lycium barbarum L. leaf tea reduced blood glucose in a dose-dependent manner. Conclusion： Lycium barbarum L. leaf tea has significant function of reducing blood glucose of alloxan induced diabetic mice.
出处
《四川中医》
2009年第4期47-49,共3页
Journal of Sichuan of Traditional Chinese Medicine
基金
宁夏自然科学基金项目(No:.NZ0715)
关键词
枸杞叶
糖尿病小鼠
降血糖
leaves of Lycium barbarum L.
diabetic mice
hypoglycemic
