摘要
目的:探讨了尖锐湿疣患者治疗前后血清TNF-α、IL-6、IL-8、IL-10水平变化及意义。方法:应用RIA和ELISA对40例尖锐湿疣患者进行了血清TNF-α、IL-6、IL-8、IL-10水平检测并与35名正常健康人作比较。结果:在治疗前尖锐湿疣患者血清IL-6及IL-8低于正常对照组。TNF-α、IL-10水平均非常显著地高于正常对照组(P<0.01),经治疗3个月后与正常对照组比较仍有显著性差异(P<0.05)。结论:检测尖锐湿疣患者血清TNF-α、IL-6、IL-8、IL-10水平的变化对疾病的治疗、预后观察有重要的临床价值。
Objective To explore the significance of changes of serum TNF - α, IL - 6, IL - 8, IL - 10 levels after treatment in patients with condyloma acuminatum. Methods Serum levels of TNF - α, IL - 8, IL - 10 （ with RIA）, IL - 6 level （ with ELISA） were measured both before and after treatment in 40 patients with condyloma acuminatum and 35 controls. Results Before treatment, the aerum TNF - α and IL - 10 levels in the patients were significantly higher, but IL -6 and IL - 8 levels were significantly lower than those in controls （P 〈0.01 ）. After treatment, the levels of cytokines were much corrected, but still remained significantly different from those in controls （P 〈 0.05 ）. Conclusion The levels of serum TNF - α, IL - 6, IL - 8 and IL - 10 changed significantly in patients with condyloma acuminatum especially in those advanced cases.
出处
《放射免疫学杂志》
CAS
2007年第6期525-526,共2页
Journal of Radioimmanology
