摘要
作者测定了３１例糖尿病病人和５０例正常人血清脂结合唾液酸（ｓＬＡＳＡ）含量，其结果分别为５６５．１８±１４５．０２μｍｏｌ／Ｌ和４３９．２８±１１８．７２μｍｏｌ／Ｌ，前者显著高于后者（Ｐ＜０．００１）。糖尿病病人（２２例）住院治疗１个月后测ｓＬＡＳＡ含量显著下降，治疗前后分别为５８１．５９±１６０．４７和４９８．４１±１５１．４９μｍｏｌ／Ｌ，差异非常显著（Ｐ＜０．００１）。在相关分析中发现血糖与ｓＬＡＳＨ含量呈正相关ｒ＝０．４９（Ｐ＜０．０１），果糖胺与ｓＬＡＳＡ之间无相关性。３１例糖尿病病人中并发症组与无并发症组的ｓＬＡＳＡ含量无差异，以上结果提示ｓＬＡＳＡ含量异常与糖尿病密切相关，并与血糖水平似相一致。
Serum lipid-associated sialic acid (sLASA) levels were measured in diabetic patients (n= 31) and compared with those in healthy controls (n=50). The results showed that the mean sLASA level in diabetics (565.18±145.02μmol/L) was significantly higher than that in the normal controls (439.28±118.72μmol/L) (P<0.001). After one month's regular treatment, the mean sLASA level in 22 diabetics (498.41±151.49μmol/L) was significantly lower than that before treatment (581.59±160.47μmol/L) (P<0.001). Statistical analysis revealed a positive correlatinship befween fasting blood glucose (FBG) and sLASA levels (r=0.49, P<0.01). But there was no relationship between fructosamine and the sLASA level. No difference in sLASA levels was found between diabetic patients (n=31) with complications and those without.
关键词
脂结合唾液酸
糖尿病
病因学
脂多糖
Lipid-associated sialic acid/blood
Diabetes millitus/etiol
Lipopolysaccharides/blood
