摘要
目的 :探讨食管癌患者手术切除前后血清CEA和TNF -α的水平变化及意义。方法 :应用放射免疫分析检测 6 8例食管癌患者血清CEA和TNF -α含量 ,术后 2个月和 6个月分别再检测一次 ,并以 32例正常健康人作对照。结果 :食管癌患者在手术切除前血清CEA和TNF -α的水平显著高于正常人组 (P <0 0 5 ) ,2个月后几乎降至正常水平 (P >0 0 5 )。手术切除后 6个月复发者血清CEA和TNF -α持续异常 ,未复发者血清CEA和TNF -α基本正常。结论 :血清CEA和TNF -α的水平与食管癌患者的病情和预后密切相关 ,具有一定的临床应用价值。
Objective To investigate the clinical significance of the operation-related changes of serum CEA and TNF-α levels in patients with esophageal cancer. Methods Serum levels of CEA and TNF-α were measured with RIA in 68 patients with esophageal cancer and 32 controls before operation. Two and six months after operation, the serum levels were again measured. Results The serum CEA and TNF-α levels in patients were significantly higher than those in controls before operation (P<0.05) and returned to almost normal two months after operation (P>0.05). Six months after operation the levels of serum CEA and TNF-α in patients who developed matastasis were abnormally high again while the levels in patients without matastasis remained normal. Conclusion The changes of the levels of serum CEA and TNF-α were closely related to the disease status and was of prognostic value in esophageal cancer.
出处
《放射免疫学杂志》
CAS
2004年第5期350-351,共2页
Journal of Radioimmanology
