摘要
目的：探索茶色素对冠心病、高血压病病人血小板功能的影响。方法：冠心病病人３６例（男性２１例，女性１５例；年龄６４±ｓ４ａ）；高血压病病人３０例（男性１８例，女性１２例；年龄５８±８ａ）。采用茶色素２５０ｍｇ，ｐｏ，ｔｉｄ，３０ｄ为一个疗程。结果：治疗后ＴＸＢ２下降，６－ｋｅｔｏ－ＰＧＰ１α上升，ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值下降（Ｐ＜０．０１或Ｐ＜０．０５），ＧＭＰ－１４０下降（Ｐ＜０．０５），ＰａｇＴ，ＰａｄＴ下降（Ｐ＜０．０５）。结论：茶色素具有降低血小板表面活性作用，抑制血小板聚集和粘附，抗血栓形成，改善微循环，对冠心病和高血压病病人起到积极的防治作用。
AIM: To study the effects of tea pigments on blood platelet function in patients with coronary heart disease and hypertension. METHODS: Thirty-six patients (M 21, F 15; age 64±s 4 a) with coronary heart disease and 30 patients (M 18, F 12, age 58±8 a) with hypertension were treated with tea pigments, 250 mg po, tid for 30 d. RESULTS: The levels of TXB 2, GMP-140, Pad T and Pag T were decreased and 6-keto-PGF 1α increased (P<0.05 or P<0.01). CONCLUSION: Tea pigments can decrease platelet surface activity, inhibit the platelet adhesiveness and aggregation, and improve microcirculation. It plays a positive role in preventing and treating coronary heart disease and hypertension.
出处
《新药与临床》
CSCD
北大核心
1997年第4期198-200,共3页
关键词
茶色素
血小板功能
高血压
冠心病
tea pigments
blood platelet function tests
hypertension
coronary disease
