2Isolan GR, Rihas Filho JM,Isolan PM,et al.Astroytic neoplasms and correlation with mutate p53 and Ki-67 proteins[J]. Arq Neuropsiquiatr,2005,63(4) : 997-1004.
3Senatus PB, Li Y, Mandigo C, et al. Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide[J].Mol Cancer Ther,2006,5(1 ) :20-28.
4Ray A, Ho M, Ma J, et al. A clinicobiologlcal model predicting survival in medulloblastoma [J]. Clin Cancer Res,2004,10(22) :7613-7620.
5Deb P, Sharma MC, Mahapatra AK, et al. Glidalastoma multiforme with long term survival [ J ]. Neurol India, 2005,53 ( 3 ) : 329-332.
6Cheng Y, Ng HK, Zhang SF, et al. Genefie alterations in pediatric high- grade astrocytomas[ J ]. Hum Pathol, 1999,30( 11 ): 1284-1290.
7Pollack IF, Hamilton RL, James CD, et al. Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort[J]. J Neurosurg, 2006, 105 (5 Suppl) : 418-424.
9Preusser M, Haberler C, Hainfellner JA, et al. Malignant glioma: neuropathology and neurobiology[ J ]. Wien Med Wochenschr, 2006, 156 ( 11-12 ) : 332-337.
10Hulleman E, Helin K. Molecular mechanisms in gliomagenesis[ J]. Adv Cancer Res,2005,94:1-27
4[1]Mcgee TL,Yandell DW,Dryja TP.Structure and partial genomic sequence of the human retinoblastoma susceptibility gene.Gene.1989,80(1):119～128.
5[2]Hong FE,Huang HJ,To H,et al.Structure of the human retinoblastoma ggene.Proc Natl Acad Sci USA.1989,86(14):5502～5506.
6[3]Mayol X,Grana X,Baldi A,et al.Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.Oncogene.1993,8(9):2561～2566.
7[4]Chellappan SP,Hiebert S,Mudryj M,et al.The E2F transcription factor is a cellular target for the Rb protein.Cell.1991,65(6):1053～1061.
8[5]Helin K,Lees JA,Vidal M,et al.A cDNA encoding a pRb-binding protein with properties of the transcription factor E2F.Cell.1992,70(2):337～350.
9[6]Hinds PW,Mittnacht S,Dulic V,et al.Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.Cell.1992,70(6):993～1006.
10[7]Ewen ME,Sluss HK,Sherr CJ,et al.Unctional interactions of the retinoblastoma protein with mammalian D-type cyclins.Cell.1993,73(3):487～497.
