摘要
背景与目的:儿童胶质瘤是小儿时期最常见的肿瘤之一,也是最常见的中枢神经系统肿瘤。本文探讨儿童颅内胶质瘤的临床特点、治疗及预后。方法:对经病理检查确诊为颅内胶质瘤的108例儿童患者的临床资料进行回顾性分析。结果:108例患者中病变位于幕上44例(40.7%),幕下64例(59.3%),其中幕上近中线处30例,幕下近中线处49例;全切79例(73.1%),次全切22例(20.4%),部分切除或活检7例(6.5%);病理结果为低级别胶质瘤93例(86.1%),高级别胶质瘤15例(13.9%);其中星形细胞瘤100例(92.6%)。99例患者得到随访,其中86例随访至今无复发,术后生存率87.8%。结论:儿童胶质瘤临床上有其特异性,肿瘤好发于幕下和近中线处,病理类型多为低级别星形细胞瘤,治疗应以全切肿瘤为主,预后相对较好。
BACKGROUND OBJECTIVE： Glioma is one of the most common intracranial tumors in childhood.The object of this areticle was to explore the clinical characteristics,treatment and prognosis of pediatric intracranial gliomas.METHODS： Clinical data of 108 children with intracranial gliomas diagnosed histopathologically were analyzed retrospectively.RESULTS： Lesions were located in supratantorial region in 44 cases（40.7%） and in infratentorial region in 64（59.3%）,respectively.Among these,30 supratantorial and 49 infratentorial lesions were located near the midline.Total resection was achieved in 79 cases（73.1%）,subtotal resection in 22 cases（20.4%）,and partial resection or biopsy in 7 cases（6.5%）,respectively.The pathological examination showed low-grade gliomas in 93 cases（86.1%） and high-grade gliomas in 15 cases（13.9%）,respectively,with 100 cases（92.6%） of astrocytomas.Ninety-nine cases were available for follow-up.Eighty-six cases had no evidence of relapse to date.The postoperative survival rate was 87.8%.CONCLUSONS： Pediatric gliomas are clinically specific and typically occur in infratentorial region and midline.The tumor pathological types are mainly low-grade astocytomas.The treatment should basically be total resection and the prognosis is usually optimal.
出处
《中国神经肿瘤杂志》
2012年第1期19-23,共5页
Chinese Journal of Neuro-Oncology
基金
四川省科技支撑项目(编号2008SZ020)
关键词
儿童
胶质瘤
治疗
预后
Children
Glioma
Treatment
Prognosis
