摘要
目的：为探讨肿瘤坏死因子（ＴＮＦ）及磷脂酶Ａ＿２（ＰＬＡ＿２）在急性肝衰竭（ＡＨＦ）时的作用及关系。方法：用Ｄ－氨基半乳糖及内毒素复制急性肝衰竭动物模型，检测其血清中ＴＮＦ含量及肝组织匀浆中ＰＬＡ、活性。结果：ＡＨＦ组鼠血清中ＴＮＦ含量及肝组织匀浆中ＰＬＡ＿２活性明显高于正常对照组（Ｐ值＜０．０５，Ｐ值＜０．０１），ＰＬＡ＿２活性与ＴＮＦ含量呈正相关关系。结论：ＴＮＦ可能激活ＰＬＡ＿２，后者与ＴＮＦ所致的肝损伤有关。
Aim: To investipte the roles of tumor necrosis factor (TNF) and phospholipase A2 (PLA2)and their effects in acute hepatic failure (AHF). Methods : We administered D-Galactosamine (D-Ga1N) 1 100mg/kg plus endotoxin (ET) 20ug/each rat to induce AHF model, then mesured the serum TNF level and PLA2 activity in the liver homogenate. Results: The results showed that the serum TNF level, PLA2 activity in the liver homogetnate were significantly higher in AHF group than those in normal group (P<0.05, P<0.01 ). The activity of PLA2 was correlated presicely with serum TNF level (r=0.8078, P<0.01 ). ConcIusion : Our results suggested that TNF and PLA2 are involved in the pathogenesis of AHF induced by D-GalN+ET. lt is possible that TNF mediated liver injury by activiting PLA2 mechanism.
出处
《中华肝脏病杂志》
CAS
CSCD
1997年第2期108-109,共2页
Chinese Journal of Hepatology
关键词
肿瘤坏死因子
磷脂酶A2
急性
肝功能衰竭
Tumor necrosis factor Phospholipase A2 Acute hepatic failure D-Galactosamine Endotoxin Rat
