摘要
为探讨重组肿瘤坏死因子－α（ｒＴＮＦ－α）、重组白细胞介素－６（ｒＩＬ－６）与内皮素－１（ＥＴ－１）在肝坏死中的作用；用Ｄ－氨基半乳糖（Ｄ－ＧａｌＮ）单独或联合ｒＴＮＦ－α，ｒＩＬ－６对ＳＤ大鼠进行腹腔注射，常规检测其肝功能及ＥＴ－１含量的变化，并通过病理学检查其肝坏死的程度。结果发现，在Ｄ－ＧａｌＮ造成肝坏死的基础上，合用ｒＴＮＦ－α，ｒＩＬ－６可增加肝坏死的程度，使血清中总胆红素（ＴＢＩＬ）、谷丙转氨酶（ＡＬＴ）及ＥＴ－１均明显升高。提示ｒＩＬ－６，ＥＴ－１在ｒＴＮＦ－α介导的肝细胞损伤中起较大的作用。
To investigate the effect of rTNF-α,rIL-6,ET-1 on liver necrosis,D-galactosamine(D-GalN) with or without rTNF-α, rIL-6 was injected into the abdominal cavity of rats separately,and the changes of serum of ALT,TBIL,ET-1 and liver necrosis were measured.The serum TBIL,ALT,ET-1 and liver necrosis of rats increased more markedly by using of rTNF-α with D-GalN than by D-GalN alone.The serum TBIL,ALT,ET-1 and liver necrosis also increased after injection of D-GalN with rTNF-α and rIL-6.The conclusion is that rIL-6,ET-1 may play an important role in process of TNF-α mediating necrosis in liver.
出处
《湖南医学》
1998年第6期332-333,共2页
Hunan Medical Journal
关键词
肝坏死
肿瘤坏死因子
白细胞介素6
动物模型
liver necrosis tumor necrosis factor interleukin-6 endothelins animals,laboratory rats
