摘要
①目的探讨硒（Ｓｅ）对急性心肌梗塞（ＡＭＩ）病人红细胞变形能力（ＥＤ）的影响及其机制。②方法检测了４２例ＡＭＩ病人和３７例健康人红细胞滤过指数（ＥＦＩ）、红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶、谷胱甘肽过氧化物酶（ＧＳＨ－ｐｘ）活性和脂质过氧化物（ＬＰＯ）的变化，同时观察了硒在体外对ＡＭＩ病人ＥＦＩ，Ｎａ＋－Ｋ＋－ＡＴＰ酶、ＧＳＨ－ｐｘ和ＬＰＯ的影响。③结果ＡＭＩ病人ＥＦＩ，ＬＰＯ明显增高，Ｎａ＋－Ｋ＋－ＡＴＰ酶和ＧＳＨ－ｐｘ活性明显降低，与对照组比较差异均有极显著性（ｔ＝４．２０６～４．９５２，Ｐ均＜０．００１）；ＡＭＩ病人红细胞与Ｓｅ在体外孵育２４ｈ后，ＥＦＩ与ＬＰＯ明显降低，Ｎａ＋－Ｋ＋－ＡＴＰ酶和ＧＳＨ－ｐｘ活性明显增高，与孵育前组比较差异均有极显著性（ｔ＝３．５０５～４．５１７，Ｐ＜０．００１），与对照组孵育前后组比较差异均无显著性（ｔ＝１．３６５～１．８４２，Ｐ均＞０．０５）。④结论Ｓｅ具有改善和提高ＡＭＩ病人ＥＤ的作用，其机制与增强红细胞膜ＡＴＰ酶和ＧＳＨ－ｐｘ活性有关。
Objective To study the effects and mechanisms of selenium on erythrocyte deformability(ED) in patients with acute myocardial infarction(AMI). Methods The erythrocyte filtration index(EFI), erythrocyte membrane Na + K + ATPase, glutathione peroxidase(GSH px) and lipid peroxide(LPO) were measured in 42 patients and 37 healthy subjects, meanwhile the effect of selenium on EFI, Na + K + ATPase, GSH px and LPO in AMI patients were observed in vitro. Results The EFI and LPO were significantly higher, Na + K + ATPase and GSH px were significantly lower in patients than those in controls( t=4.206￣ 4.952, P <0 001); AMI patients erythrocytes were incubated with selenium for 24 hours, the EFI and LPO were markedly lower, Na + K + ATPase and GSH px were markedly higher than those before the incubation( t=3.505￣4.517,P <0 001), but there were no significant differences compared with the healthy subjects before and after the incubation( t=1.363￣1.842,P >0 05). Conclusion Selenium can improve the ED in AMI patients, and the mechanism may be related to the enchancement of erythrocyte membrane ATPase and GSH px activity.
出处
《青岛医学院学报》
1997年第1期22-24,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
心肌梗塞
AMI
红细胞变形能力
硒
GSH-PX
coronary artery disease
erythrocyte deformability
selenium
adenosine triphosphatase
glutathione peroxidase
