摘要
目的:观察石仙桃提取物对小鼠运动疲劳和缺氧的影响。方法:应用5种运动疲劳和缺氧实验,如:常压耐缺氧实验、特异性心肌缺氧实验、亚硝酸钠引起的缺氧实验、对抗脑缺血缺氧和耐力实验等。结果:①常压耐缺氧实验中,腹腔注射石仙桃提取物呈剂量依赖性,明显延长小鼠生存时间。②特异性心肌缺氧实验中,腹腔注射石仙桃明显延长小鼠生存时间。③在亚硝酸钠引起的缺氧实验中,预防性给石仙桃提取液可延长小鼠存活时间。④对抗断头术后脑缺血缺氧实验中,石仙桃提取液能显著性延长小鼠喘息时间。⑤在耐力实验中,石仙桃提取液呈剂量依赖性延长小鼠存活时间。结论:石仙桃具有抗疲劳作用、耐缺氧作用,其潜在的作用机制可能与提高肺泡液清除有关。
Objective：To study the fatigue - resisting and anoxia - resisting effect of the abstract of Pholidota chinensis lindl on mice. Methods ： there are 5 kinds of anoxia models, such as ： the test of the tolerance to anoxia under normal pressures, the test of the specificity myocardium under hypoxia, the test of the antagonism of sodium nitrite, and the celebral hypoxia - ischemia test ,and the test on exercise tolerance in mice. Results： （1） In the study of extract on the ability of hypoxia endurance at normal pressure, result showed the mice survival time at normal pressure prolonged by extracts;（2） In the study of the effects of extract on specific anoxic myocardium, results showed the mice survival time prolonged by extracts ;（3） In the study protective effects of extract on survival time after peritoneal injection NaNO2 in mice. Iintraperitoneally treated with extracts; （4） In the study of the effects of extract on cerebral ischemia and hypoxia after decapitation, the gasping duration was prolonged by extracts in mice;（5）In the test on exercise tolerance in mice. The result showed the survival time of the swimming was prolonged by extracts in a dose -dependent manner. Conclusion： pholidota chinensis lindl, has effects of anti - fatigue, anti - hypoxia through potential mechanism of the increase of alveolar fluid clearance.
出处
《赣南医学院学报》
2007年第2期177-179,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
石仙桃
抗疲劳
耐缺氧
Pholidota chinensis lindl
anti - fatigue
anti - hypoxia
