摘要
目的 探讨扶正化瘀补肾壮骨对老年小鼠骨质疏松的影响。方法 实验用小鼠 60只 ,1 5只 (6月龄 )为青年组 ,另 45只 (2 4月龄 )则随机分为老年组、地塞米松组和中药组。地塞米松组和中药组注射地塞米松 (0 0 0 1 mg g) ,每周 2次 ,共 1 2 w。从第 1 3周至第 2 0周停止注射地塞米松。中药组给予口服中药。于第 2 0周末 ,处死所有动物 ,测量股骨体积 ,整骨钙量 ,计算单位体积钙含量。结果 青年组钙含量 (0 360 6± 0 0 4 3 1 g cm3 )高于老年组 (0 2 2 1 5± 0 0 2 6 3 g cm3 ) (P<0 0 1 )。中药组 (0 1 878± 0 0 1 95 g cm3 )高于地塞米松组 (0 1 689± 0 0 2 3 0 g cm3 ) (P<0 0 5) ,但低于老年组 (P<0 0 1 )。结论 扶正化瘀补肾壮骨可有效治疗老年性骨质疏松。
To study the effect of Fuzheng Huayu Bushen Zhuanggu Recipe(FHBZR) on osteoporosis in old male mice.Methods 60 male mice were divided:(1)young group n=15(6 months). (2)aged group n=15;(3)dexamethasone group n=15 and FHBZR group n=15. The Dexamethasone and FHBZR group were injected with dexamethasone 2 times a week for 12 weeks, From 12 to 20 weeks, the FHBZR group were given Chinese medicine animals were all sacrifized. At the 20 week, and the anatomical volume of the right femora were mearsured by displacement of water and the weight of calcium were determined.Results The calcium content in young group(0 360 6±0 043 1 g/cm 3) was higher than that of aged group(0 221 5±0 023 6 g/cm 3) (P<0 05) , the FHBZR group(0 187 8±0 019 5 g/cm 3) (P<0 05) and that of the Dexamethasone group(0 168 9±0 023 0 g/cm 3) (P<0 05) .Conclusions FHBZR was effective for the treatment for osteoporosis in old male mice.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2000年第1期41-41,共1页
Chinese Journal of Gerontology
基金
湖北省教委科学基金!97A0 4 2
