摘要
目的:研究己酮可可碱(Pentoxifylline,PTX)对家兔脑缺血再灌注损伤(IRI)的保护作用。方法:家兔30只,随机分为假手术组、对照组、己酮可可碱组,后两组复制脑缺血再灌注损伤模型;24h后检测脑组织匀浆的超氧化物歧化酶(SOD)、丙二醛(MDA)、Na+-K+-ATP酶、肿瘤坏死因子-α(TNF-α)含量,并用电镜和光镜作病理观察。结果:PTX能部分减轻由于IRI所引起的神经元细胞的破坏性改变。再灌注24h后PTX组比较对照组:SOD、Na+-K+-ATPase,活性明显升高(P<0.01);MDA和TNF-α明显降低(P<0.05)。结论:己酮可可碱对家兔脑缺血再灌注损伤具有保护作用。
To observe the protective effect of Pentoxifylline （PTX） on ischemiareperfusion injury in ratbbits brain. Methods： 30 rabbits were randomly divided into 3 groups： pentoxifylline, sham, and control. Model of cerebral ischemia-reperfusion injury in rabbits brain was used to study the effect of pentoxifylline through measuring the activity of SOD, the content of MDA. Na＋-K＋-ATP enzyme and TNF α, meanwhile the pathological structure were observed under electron microscope and light microscope. Results： Pentoxifylline decreased neurolonical deficit caused by ischemia-reperfusion injury. Conclusion： PTX has a protective effect against ischemia-reperfusion injury in rabbits brain.
出处
《温州医学院学报》
CAS
2006年第3期201-203,共3页
Journal of Wenzhou Medical College
基金
温州市科技局科研基金资助项目(y2004a051)。
关键词
己酮可可碱
脑缺血
再灌注损伤
动物实验
Pentoxifylline
cerebral ischemia
reperfusion injury
animal experiment
