摘要
目的:探讨老年食管癌加速超分割放射治疗的疗效、毒副作用和并发症。方法:将96例患者随机分为常规治疗组(CF)和加速超分割治疗组(CAF)。CF组:每次1.8～2.0Gy,总剂量60～70Gy/30～35fx。CAF组:每天照射2次,每次1.5Gy,总剂量54Gy/3.5w,两组患者均用60Co-γ射线外照射。结果:两组患者均顺利完成了疗程,其1、3、5年生存率CF组分别为45.8%(22/48)、18.8%(9/48)、12.5%(6/48);CAF组分别为70.8%(34/48)、39.6%(19/48)和29.2%(14/48),CAF组疗效明显优于CF组(P<0.05)。毒副作用主要表现为放射性食管炎和放射性气管炎,但均无统计学差异。并发症中,早期以食管穿孔、食管出血为主要表现,晚期主要表现为食管缩窄、咯血及持续性咳嗽,两组相比无统计学意义。结论:CAF组患者能耐受根治性放疗;CAF组患者放疗的毒副作用及并发症较CF组明显,但两组发生率无统计学意义。
Objective： To investigate the result, toxic effect and complication of accelerated hyperfractionation radiotherapy for elderly patients with esophageal carcinoma. Methods： From December 1990 to July 1992, 96 cases with esophageal carcinoma were enrolled in the study. They were divided into two groups by stratified randomization as follow： a） The patients in the conventional fraetionation group （CF） received routine radiotherapy 60-70Gy/（30-35fx） and b） those in the group of continuously accelerated fraetionation radiotherapy （CAF） received 54Gy/3.5w, 2fx/d. The same Cobalt 60 radiotherapy was used in both groups. Results： The radiation treatments were able to be complicated without any break. The survival rate of 1, 3 and 5 in the CF group was 45.8% （22/48）, 18.8%（9/48） and 12.5% （6/ 48）, and was 70.8% （34/48）, 39.6% （19/48） and 29.2% （14/48） in the CAF group, respectively. The toxic effects were mainly radiation esophagitis and radiation tracheitis, but there was no significant difference. The early complications were mainly esophageal bleeding and esophageal fistula, and the later complication were mainly esophageal stenosis, haemoptysis and continuous cough, but there was no significant difference, too. Conclusions： CAF can be tolerated by most patients with esophageal carcinoma; the toxic effect and complication of CAF are more severe than that of CF, but there is no significant difference.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第7期386-388,共3页
Chinese Journal of Clinical Oncology
关键词
老年食管癌
加速超分割
放射疗法
毒副作用
Elderly patients with esophageal neoplasms Accelerated hyperfractionation radiotherapy Radiotherapy / Toxic effect
