摘要
目的 :探讨加速超分割放射治疗食管癌的疗效及放射反应和并发症。 方法 :80例胸段食管癌患者随机分为常规分割放疗组 (常规组 )和加速超分割放疗组 (加速超分割组 )。常规组 40例 ,每天照射 1次 ,每次 2 Gy,每周 5次 ,总剂量 70 Gy。加速超分割组 40例 ,其前 2 / 3疗程放射方法同常规组 ,剂量 40 Gy,后 1/ 3疗程每天照射 2次 ,每次 1.5 Gy,2次间隔时间 6 h以上 ,总剂量 70 Gy。所有患者采用 10 m V X线照射。 结果 :加速超分割组的 3年实际生存率和原发肿瘤控制率明显高于常规组 ,分别为 42 .5 %比 2 0 .0 %和 5 2 .5 %比 2 5 .0 %。两组的放射反应和并发症无显著差异 ,所有患者按计划完成了治疗。 结论 :加速超分割放疗食管癌较常规分割放疗明显提高了局控率和生存率 ,放射反应和并发症无明显增加 。
Objective: To investigate the efficacy and toxic reaction of the accelerated hyperfraction radiotherapy for esophageal carcinoma. Methods: Eighty patients with esophageal carcinoma were randomized into the conventional fraction group (CF,40 cases) and the accelerated hyperfraction group (AHF,40 cases) from January 1994 to May 1995. CF group received a fraction dose of 2 Gy once a day, 5 times a week and to a total dose of 70 Gy. AHF group received the same dose as the CF group during the first two thirds of the therapeutic course(40 Gy),then followed by a fraction dose of 1.5 Gy one time twice a day, with an interval of more than 6 hours, and to a total dose of 30 Gy. The total dose of 2 stages was 70 Gy. The same 10 mV linear accelerator X ray radiotherapy was used in both groups. Results: The 3 year actual survival and tumor local control rates in the group AHF were significantly improved compared with group CF, being 42.5% vs 25% and 52.5% vs 25% respectively. There were no significant differences in radiation reactions and complications between 2 groups. The radiation treatment could be completed without any break. Conclusion: The accelerated hyperfraction radiotherapy can improve the tumor local control and survival rates in esophageal carcinoma. The radiation reactions and complications with the AHF radiotherapy are not significantly greater than with the CF radiotherapy. The patients can tolerate the AHF radiotherapy. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第8期768-770,共3页
Academic Journal of Second Military Medical University
关键词
食管肿瘤
加速超分割放射治疗
放射损伤
esophageal neoplasms
accelerated hyperfraction radiotherapy
radiation injuries
