摘要
目的 :评价化疗加后程加速超分割放射治疗食管癌的疗效。方法 :118例食管癌患者 ,随机分为 2组 (化放组与单放组 ) ,每组 5 9例。放疗采用 6MVX线外照射 ,前 2 / 3疗程常规放射治疗 2Gy/次 ,共 4 0Gy ;后 1/ 3疗程改用加速超分割放射治疗 (2次 /天 ,1 35～ 1 4Gy/次 ) ,全疗程总剂量共 6 7～ 6 8Gy ,4 0分次 ,4 0～ 4 2天完成 ;化疗采用FP方案 (5 氟脲嘧啶和顺铂 )。结果 :化放组与单放组的 1、2年生存率分别为 86 4 %、6 9 5 %和 72 9%、5 0 8% (χ2 =3 95 ,4 2 8,P <0 0 5 ) ,其中 3、4年生存率分别为 4 9 2 %、4 2 4 %和 4 0 7%、33 9% (χ2 =0 86 ,0 89,P >0 0 5 )。结论 :化疗加后程加速超分割放射治疗食管癌能提高患者的近期生存率 ,并未增加毒性反应。
Objective:To evaluate the effect of chemotherapy plus late course accelerated hyperfrationation radiotherapy (LCAHR) for esophageal carcinoma.Methods:From April 1996 to March 1998, 118 patients with esophageal carcinoma were randomized into two groups. Fifty nine patients received chemotherapy plus radiotherapy (CT RT group), 59 received radiotherapy (RT group). All patients were given with 6MV X ray , total tumor dose was 40Gy/20F, with conventional fractionation regimen during the first two thirds of the course, and followed by LCAHR, 1 35～1 4Gy per fraction, twice daily. The total dose Varied up to 67～68Gy/40F/40～42d, chemotherapy regimen was FP (5 Fu and DDP).Results:The 1 and 2 year survival rate in CT RT group and RT group were 86 4%,69 5% and 72 9%,50 8% respectively (χ 2=3 95,4 28, P <0 05).Conclusion:Chemotherapy plus LCAHR can increase the recently survival rate in patients with esophageal carcinoma without severe toxicities.
出处
《临床肿瘤学杂志》
CAS
2003年第2期110-111,共2页
Chinese Clinical Oncology
关键词
食管肿瘤
药物疗法
超分割放射治疗
Esophagen neoplasms
Drug therapy
Accelerated fractionation radiotherapy
