摘要
目的 探讨后程加速超分割 (LCAF)放射治疗老年食管癌的疗效和预后因素。方法 回顾性分析 10 5例年龄≥ 6 0岁的老年食管癌接受LCAF根治性放射治疗 (6 7.9～ 72 .0Gy ,39～ 4 3次 ,4 2～ 5 3d)的疗效。结果 急性放射反应主要是急性放射性食管炎和急性放射性气管炎 ,多为 1～ 2级。5年总生存率为 34.4 % ,5年局部控制率为 6 3.7% ,5年无瘤生存率为 2 2 .6 %。 6 0～ 6 9、70～ 80岁年龄组近期疗效和急性放射性气管炎和食管炎差异无显著性意义 (χ2 =2 .4 1,P =0 .12 0 ;χ2 =1.5 3,P =0 .82 1;χ2 =1.75 ,P =0 .782 )。多因素预后分析显示T分期和卡氏评分等参数与预后相关。 6 7例死亡中复发 31例 ,远地转移 2 3例 ,复发并远地转移 8例 ,其他原因 5例。结论 LCAF放射治疗能为老年食管癌患者耐受 ,对一般状况较好者可达到延长生存期和改善生存质量的治疗目的。
Objective To study the clinical results and prognostic factors of late course accelerated hyperfractionation radiotherapy (LCAHR) in the treatment of esophageal carcinoma in the elderly. Methods 105 over 60 year-old patients with esophageal carcinoma who received radical LCAHR, were retrospectively analysed. Radical tumoricidal dose of 67.9～72.0?Gy was delivered in 39～43 fractions over 42～53 days. Results The 5-year local control rate was 63.7%. The 5-year disease-free survival and overall survival rate were 22.6% and 34.4%. Acute esophagitis and bronchitis were the most common but acceptable radioreactions Grade 1～2. No significant differences were found either in the clinical response or complication, between the 60～69 year and 70～80 year groups. By multivariate analysis, T stage and KPS score were two independent prognostic factors. Of 67 death cases, 31 died of local relapse, 23 of distant metastases, 8 of both and 5 of other causes. Conclusions LCAHR toxicity ,being tolerable for the older esophageal carcinoma patients,may improve their survival and quality of life.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2003年第2期82-85,共4页
Chinese Journal of Radiation Oncology
