摘要
目的通过测定78例糖尿病患者及36例正常人血清铜蓝蛋白(ceruloplasmin,CP)水平,探讨CP 在糖尿病发生发展中的意义。方法将受试对象分为4组,分别采用免疫终点法测定血清CP。结果糖尿病组血清CP水平显著低于正常对照组(P<0．05);糖尿病组治疗前血清CP水平较治疗后显著降低(P<0．01);1型和2型糖尿病患者血清CP水平差异无统计学意义(P>0．05);2型单纯糖尿病组与合并慢性并发症组血清CP 水平差异无统计学意义(P>0．10)。结论血清CP水平对于糖尿病患者的诊断及治疗效果的判断具有一定参考意义。
Objective To explore the role of ceruloplasmin, an anti-oxidant, in the development of diabetes mellitus（DM）. Methods Serum concentration of ceruloplasmin （CP） ,a protein with anti-oxidant activity, was assessed in 78 DM patients as well as 36 controls. The participants were divided into 4 groups： controls, Type 1 DM patients, Type 2 DM patients and Type 2 DM patients with chronic complications. The measurement of ceruloplasmin concentration was carried out with Beckman-cx5 automatic biochemical analytical machine using immuno-end-point method. Results In comparison to that of the controls, CP concentration of the DM patients were remarkably decreased. Furthermore, in Type 2 DM patients, CP concentration after insulin treatment was also significantly reduced. Conclusions CP concentration in the serum may be considered as an important molecular marker in the diagnosis and treatment of Diabetes Mellitus.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2006年第2期168-169,共2页
Chinese Jouranl of Endemiology
基金
教育部优秀青年教师教学资助计划(1987-2002)
高等学校博士学科点专项科研基金资助项目(20040226001)
关键词
铜蓝蛋白
糖尿病
血糖
Ceruloplasmin
Diabetes mellitus
Blood glucose
