摘要
单胺氧化酶B(MAOB)是一类黄素依赖性蛋白酶,由520个氨基酸构成,通过C端的跨膜螺旋结合于线粒体外膜。MAOB基因定位于X染色体,核心启动子位于-246/-99。MAOB基因表达受多种因素调控。MAOB在多巴胺代谢途径中发挥重要作用。可将多巴胺降解为二羟苯乙酸,并生成过氧化氢。MAOB基因敲除小鼠对神经毒素1-甲基-4-苯基-1,2,3,6-四羟嘧啶(MPTP)具有耐受性。MAOB分布于脑内特定脑区,在多种神经元退行性疾病中发现脑内MAOB活性升高。MAOB可能发挥着调节氧化应激、参与神经元退行性变等作用。
Monoamine oxidase B （MAOB） is one of flavin-dependent enzymes, which is constructed by 520 amino acids, h binds to the mitochondrial outer-membrane through a C-terminal transmembrahe helix. MAOB gene is located at X chromosome and its core promoter is located at -246/-99. MAOB gene expression is modulated by several factors, h can convert dopamine to DOPAC and produce hydrogen peroxide. MAOB gene knock-out mice are resistant to the neurotoxin, 1-methyl-4-phenyl-1,2,3,6- tetrahydropyfidine. MAOB is distributed in the special cerebral regions. The activity of MAOB is detected to increase in many kinds of neurodegenerative diseases. It may be involved in modulation of the oxidative stress and process of neurodegenerative diseases.
出处
《国际病理科学与临床杂志》
CAS
2006年第1期67-70,共4页
Journal of International Pathology and Clinical Medicine
关键词
单胺氧化酶B
神经元退行性变
氧化应激
monoamine oxidase B
neurodegenerative diseases
oxidative stress
