摘要
钙蛋白酶是一类依赖钙离子浓度激活的蛋白酶,通过剪切其底物蛋白发挥不可逆调节作用。此类蛋白酶广泛存在于人体各个脏器。钙蛋白酶参与细胞骨架和细胞膜的构型重建等重要生理过程。病理状态下钙蛋白酶的异常活化是脑外伤、脑缺血、脊髓损伤等神经元退行性变、白内障形成及缺血/再灌注损伤的重要机制之一。近年来钙蛋白酶在肝细胞损伤中的作用引起极大关注。该文将对钙蛋白酶基本生理功能及在肝损伤发展过程中的作用加以综述。
Calpains are calcium-modulated proteases which respond to Ca^2＋ signals by removing limited portions of protein substrates, thereby irreversibly modifying their functions. Members of ealpains are present in a variety of organisms in human. Calpains mediates crucial cellular functions, including rearrangement of cytoskeletal proteins and protein cleavage to activate various receptors and pro-enzymes. The abnormal activation of calpains is one of the important mechanisms in several pathogenesis, including neurodegenerative diseases, traumatic brain and spinal cord injuries, cataracts and ischemia-associated injuries. The recent findings on the role of calpains and its inhibitors in the liver injury will be reviewed in this paper.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第6期708-711,共4页
Chinese Pharmacological Bulletin
关键词
钙蛋白酶
肝
损伤
calpains
liver
injury
