摘要
对七种癌症百余例血清样本,研究了肿瘤免疫因子(TDSF)对T细胞游活和白细胞介素2(IL2)反应性的作用。结果表明,各种癌症患者血清对T细胞激活和IL2反应性均表现强烈抑制。根治手术后两周,抑制活性下降,4周消失,复发后又回升至原有水平。结果提示:(1)癌患者血清中的TDSF对IL2治疗具有不利作用。IL2必须配合手术或其它疗法,使血清中TDSF降低,才能充分显示疗效。(2)以上两个检测项目可用于癌发生及复发的辅助诊断。
The effects of tumor-derived immunosuppressive activities on T cell activation and it's responsiveness to IL-2 were determined over hundred serum samples from 7 kinds of cancers. The results indicated that both T cell activation and it's responsiveness to IL-2 were strongly inhibited by-sera from all cancer patients. After radical curative operation , the immunosuppressive activities in sera of cancer patients declined rapidly in 2 weeks, disappeared in 4 weeks and re-raised to original level after recurrence . These results suggested that;lithe presence of immunosuppressive activities in patients' serum obviously has an adverse effect on the use of IL-2 in the cancer immunotherapy . We suppose that the therapeutic effect of IL-2 in cancer immunotherapy can be achieved satisfactorily, only if it is combined with curative operation or other therapeutic approaches to eliminate the immunosu ppressive activity in the serum. 2)these two assays , i. e. the inhition of T cell activation and IL-2 responsiveness, may be used as complementary parameters for the diagnosis of ca ncers and it's relapse after therapy.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第5期342-345,共4页
Chinese Journal of Cancer
基金
中国科学院自然科学基金
