摘要
人宫颈癌细胞产的免疫抑制因子（ＴＤＳＦ）作用于人外周血单个核细胞（ＰＢＭＣ）６小时，即可抑制ＩＬ－２产生，与对照组相比Ｐ＜０．０１。当ＴＤＳＦ存在时，经激活的ＰＢＭＣ效应细胞对外源性ＩＬ－２反应显著减弱，表明ＴＤＳＦ能抑制ＩＬ－２的作用。ＰＨＡ－Ｐ刺激ＰＢＭＣ增殖，但ＴＤＳＦ使其增殖抑制。表明ＴＤＳＦ能抑制ＩＬ－２产生及其作用。抗癌药对ＴＤＳＦ的分泌有部分阻抑作用。
Cervical cancer cell lines produced a tumor-derived immunosuppressive factor (TDSF), which inhibited the production of IL-2 after 6h incubation with PBMC,the response of PBMC treated with PHA-P to exogeneous IL-2 was significantly decreased in the presence of TDSF, suggesting that could inhibit the res poinsiveness of IL-2. The effect of PBMC after being stimulated with PHA-P was significantly suppressed by TDSF in does-dependent manner. These finding suggest that the in hibitory action of TDSF on T cell activation and proliferation mediated with IL-2.The synthesis or secretion of TDSF in cervical were partially inhibited by anticancer drugs.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1996年第6期338-340,共3页
Cancer Research on Prevention and Treatment
关键词
宫颈肿瘤
免疫抑制因子
白细胞介素
Cervical cancer cell line
Tumor-derived immunosuppressive factors
Interleukin-2.
