摘要
目的应用终末期肝病模型(MELD)预后分析研究不同剂量甘利欣对慢性重型肝炎的治疗作用。方法123例慢性乙型重型肝炎随机分成对照组、观察A组、观察B组,对照组43例采用一般综合治疗,观察A组40 例在对照组基础上加用甘利欣300 mg静脉滴注,1次/d,疗程1周,之后甘利欣减量为150 mg,疗程共4周。观察B 组40例在对照组基础上加用甘利欣150静脉滴注,1次/d,疗程4周。结果治疗后1周MELD评分在观察A,B 两组分别下降至26.68±6.23,26.23±6.52,较对照组29.82±6.46明显下降(P=0.016,P=0.016)。4周后MELD 评分分别下降至23.48±8.97,27.54±8.52,较对照组31.88±10.12明显下降(P=0.001,P=0.04),观察A组下降更明显。治疗后3月对照组总有效率32.56%(14/43),观察A组70%(28/40),观察B组60%(24/40),两观察组较对照组P<0.05。对照组病死率23.3%(10/43),观察A组12.5%(5/40),观察B组12.5%(5/40),较对照组均P< 0.05。结论甘利欣治疗慢性重型肝炎有良好效果,早期予大剂量疗效更为显著。
Objective To investigate the efficacy of diammonium glycyrrhizinate injection on chronic severe hepatitis. Methods 123 cases of chronic severe hepatitis caused by hepatitis B virus were allocated into control group, treatment group A and treatmentg roup B. 43 patients in the control group followed general routine treatments. 40 patients in treatment group A received diammonium glycyrrhizinate injection, with the initial dose of 300mg per day for the first week and subsequently reduced to 150 mg per day for the following 3 weeks by intravenous drip, in addition to routine treatment. 40 patients in treatment group B received diammonium glycyrrhizinate injection with the dose of 150 mg per day for 4 weeks by intravenous drip. Results The MELD score of patients in treatment group A and treatment group B after 1 week of treatment was 26.68 ± 6.23 and 26.32 ± 6.52, respectively. Both were singnificanfly reduced compared with 29.82 ± 6.46 in the control group（ P = 0.016 and 0.016）. The MELD score after 4 weeks of treatment was 23.48 ± 8.97 in treatment group A and 27.54 ± 8.52 in treatment group B. Both were significantly reduced compared with 31.88 ± 10.12 in the control group（ P = 0.001 and 0.04）. The total effective rate after 3 months of treatment was 32.56%（14/43） in the control group, 70% （28/40）in treatment group A and 60%（24/40） in treatment group B with significant differences（ P 〈 0.05）. The mortality was 23.26% （10/43） in the control group, 12.5% （5/40） in treatment group A and 15 % （6/40）in treatment group B with significant difference. Conclusion Diammonium glycyrrhizinate injection is effective for chronic severe hepatitis. The application of large dose of diammonimn glycyrrhizinate injection in earlier stage of chronic severe hepatitis has better efficacy.
出处
《广东医学》
CAS
CSCD
北大核心
2005年第8期1036-1038,共3页
Guangdong Medical Journal
