摘要
用免疫组织化学ABC法,研究了16周至新生儿听皮质含SS神经元的发育.含SS神经元最早出现在24周,少数散在的含SS神经元分布在脑室下层、套层,多数分布在皮质Ⅳ到Ⅵ层.随后向浅层发育.提示发育顺序似从深层向浅层发育,深层含SS神经元发育、分化、成熟比浅层早.含SS神经元的胞体平均截面积随发育过程逐渐增大,但不匀速.低胎龄,突起数少而短,双极和多极神经元比例接近,随胎龄增大,多极神经元逐渐比例增高.皮质和皮质下白质散在分布合SS神经纤维.对新生儿听皮质各层含SS神经元进行灰度分析,听皮质含SS神经元的灰度从浅层到深层渐减.提示含SS神经元的活性深层比浅层高.含SS神经元的数量随胎龄增大呈增加趋势,孕期终末增幅明显,可能是发育活跃期,可能与生后语言功能发育有一定关系.
Prenatal development of SS-ontaining neurons in the human fetus auditory cortex, prenatal age ranging from 16 weeks to a full term newborn infant was studied immunocy-tochemically with ABC method. SS-containing neurons early appeared in 24 weeks, a small numbers in subventricular zone and mantle zone, and a greater numbers in Ⅳ toⅥ layers. SS-containing neurons migrate towards superficial layers as developing in older age. Gray gradient of SS-containing neurons in various layers of auditory cortex of newborn was compared. It shows that the gray gradient decreased from deep to superficial layers gradually. It suggested that SS activity of SS-containing neurons in deeper layers is greater than in superficial layers. Mean area of cell body of SS-containign neurons increased with gestation age. But is not uniform. In early stage numbers of processes are less and short, percentage of bipolar neurons is greater, on the contrary the percentage of multipolar neurons increased in elder ages. The numbers of SS-containing neurons increased most obviously in newborn infant. It may suggest this may relate to the postnatal development of the function of language.
关键词
人胎
听皮质
生长抑素
发育
神经元
Human fetus
auditory cortex
somatostatin
development
