摘要
本实验以PAP免疫组织化学方法观察了老年雄性大鼠下丘脑生长抑素(SRIF)神经元系统的变化,结果表明老年大鼠室周核(PV)SRIF神经元群中,除视前室周核(Pep)内阳性细胞减少外,其余部位的阳性细胞增加(P<0.05),并且正中隆起(ME)处染色增强。此外,在内侧视前区(MPO)和弓状核(ARN)的阳性纤维减少,视交叉上核(SCN)内阳性细胞和纤维均减少,而在腹内侧核背内侧区(VMNdm)阳性纤维明显增加。本实验结果提供了下丘脑SRIF神经元老年时期发生不均一性变化的形态学证据。
The change of SHIF-immunoreactive neurons of old rat hypothalamus wasdemonstrated by PAP techniqne. The results showed that the numbers of SRIF-neurons in periventricnlar nuclei (Pv) were increased except preoptic periventricnlarnuclei (Pep) and staining in external Zone of median eminence (ME)was alsostrengthened. The density of postive fibers in medial preoptic area (MPO), arcuatenuclei (ARN) and superchaismatic nuclei (SCN) were decreased. While in the dor-somedial area of ventromedial hypothalamic nuclei (VMN), the SRIF-immunorea-ctive fibers were obvionsly increased. These data provide morphological evidence.for the change of SRIF-immunoreactive nearons of hypothalamns in aging rats.
出处
《老年学杂志》
CSCD
1989年第3期163-165,192,共3页
关键词
下丘脑
生长抑素
神经元
大鼠
Hypothalamic somatostatin neuron
Aging
Immunohistochemistry
