摘要
本文应用微核试验方法对β－胡萝卜素拮抗ＨｇＣｌ_２致小鼠骨髓多染红细胞的微核作用进行研究，结果表明：（１）β－胡萝卜素５ｍｇ／ｋｇ体重及以上剂量时可显著地降低ＨｇＣｌ_２ｌ．０ｍｇ／ｋｇ体重的致小鼠微核作用（Ｐ＜０．００１）；（２）β－胡萝卜素在ＨｇＣｌ２染毒前４ｈ内和染毒后２ｈ内给予小鼠时，均有明显地拮抗致微核作用（Ｐ＜０．００５和Ｐ＜０．００１）；（３）隔日给小鼠β－胡萝卜素２．５ｍｇ／ｋｇ体重一个月后也可明显地减少ＨｇＣｌ_２的致微核作用（Ｐ＜０．００１）.
In this paper,antagonistic effects ofβ
-carotene on the rate of micronuclei in themice bone marrow polychromatic erythrocyte induced
by mercuric chloride (HgCl2)was studiedusing the micronucleus test method.The results are as
follows:(1)The rate of micronuclei inducedby the combingβ-carotene 5mg/kg or more plus
HgCl2 lmg/ kg was much lower than that ofHgCl2 control group(P< 0.001);(2) When the mice
received β-carotene 240 min before and l20min after with HgCl2, the rate of micronuclei was
lower than that of HgCl2 control group(P<0.05and P< 0.001);and(3)The antagonistic effect of
micronuclei caused by HgCl2 lmg/kg was alsoobvi ous after the mice were given β-carotene 2.
5 mg / kg every two days for a month(P<0.001)。
出处
《蚌埠医学院学报》
CAS
1994年第1期15-18,共4页
Journal of Bengbu Medical College
关键词
β
胡萝卜素
氯化汞
微核试验
β-carotene
mercuric chloride
(HgCl2)
micronucleus test
mice
