摘要
目的：探讨氯化汞（ＨｇＣｌ２）对小鼠毒性作用。方法：采用毒理学方法观察ＨｇＣｌ２对小鼠体重、脏器系数和精子畸形率的影响，并作Ｆ检验和ｑ检验以及ｕ检验。结果：ＨｇＣｌ２２．０ｍｇ／ｋｇ和１．０ｍｇ／ｋｇ体重染毒后体重增长明显低于阴性对照组（Ｐ＜０．０５～Ｐ＜０．０１）；ＨｇＣｌ２２．０ｍｇ／ｋｇ体重组肝脏器系数明显高于ＨｇＣｌ２１．０ｍｇ／ｋｇ组和阴性对照组（Ｐ＜０．０１），而肾、脾脏器系数均显著低于ＨｇＣｌ２１．０ｍｇ／ｋｇ体重组和阴性对照组（Ｐ＜０．０５～Ｐ＜０．０１）；精子畸形率也较对照组显著升高（Ｐ＜０．０１）。结论：ＨｇＣｌ２对小鼠具有显著地毒性作用。
Objective:Toxicity effect of mercuric chloride(HgCl 2) was studied in mice.Methods:The effect of HgCl 2 on the body weight,the organs index and the rate of aberration of sperm in mice were observed.The toxicity was calculated statistically in F test, q test and u test were supplied.Results:The body weight of mice of HgCl 2 group was significantly lower than that of control group( P <0.05～ P <0.01).The liver organ index of mice with HgCl 2 in dose of 2.0 mg/kg group was higher than that of 1.0 mg/kg group and control group( P < 0.01 ).The kidney and spleen organ index of mice with HgCl 2 in 2.0 mg/kg group was obviously lower than that of 1.0 mg/kg and control( P <0.05～ P <0.01).The rate of sperm aberration in HgCl 2 group was also higher than that of control group( P < 0.01 ).Conclusions:The toxicity effect of HgCl 2 was significant in mice.
出处
《蚌埠医学院学报》
CAS
1999年第1期1-2,共2页
Journal of Bengbu Medical College
基金
安徽省教育委员会自然科研基金
关键词
氯化汞
毒性作用
小鼠
mercuric chloride
toxicity
mice
